Head-to-head comparisons of medication uses, side effects, warnings, and more.
Ciclopirox (Loprox, Penlac) and Jublia (efinaconazole) are both prescription antifungal medications, but they have some key differences. Ciclopirox is available in various forms, including cream, gel, shampoo, suspension, and nail lacquer, and can treat a wide range of fungal infections on the skin, nails, and scalp. In contrast, Jublia is only available as a topical solution specifically for treating toenail fungus. Ciclopirox has a generic version, making it a more affordable option, while Jublia is only available as a brand-name medication. Treatment duration also varies: ciclopirox nail lacquer can take up to a year to show results, similar to Jublia, which requires daily application for 11 months. Additionally, ciclopirox requires weekly removal of the nail lacquer with rubbing alcohol, whereas Jublia does not. Both medications should not be used with nail polish, but Jublia is flammable and should be kept away from open flames.
Ciclopirox works well for various types of fungal skin and nail infections. It's available as a cream, gel, shampoo, suspension, and topical solution. Different formulations of ciclopirox can treat different medical conditions. This medication applied directly to the affected area(s), anywhere from twice daily to twice weekly, depending on what medical condition you have and what formulation of ciclopirox you're prescribed. It typically takes a week to a month before you notice improvements to your condition. But it can take 6 months or longer to see improvements for certain nail infections.
Jublia (efinaconazole) topical solution is an azole antifungal. It's applied directly to the toenail(s) once daily to treat toenail fungus. Treatment with Jublia (efinaconazole) typically lasts 11 months. Most people don't experience side effects from this medication, but some have reported ingrown toenail and application site reactions (e.g., irritation, pain). Jublia (efinaconazole) is prescription-only and there are no generic medications available.
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