Hydroxypyridone antifungals are used to treat fungal infections of the skin, such as jock itch, athlete's foot, and ringworm. They also have other uses, such as treating fungal infections of the nail and scalp. These medications work by blocking the fungi from growing, which helps to clear up the infection. Hydroxypyridone antifungals come in different forms, including creams, gels, shampoos, and nail lacquers. Examples include ciclopirox (Loprox). You can choose the form that best fits your needs.