Key takeaways:
You should apply Jublia (efinaconazole) to clean, dry toenails once daily for 48 weeks (about 11 months). Be sure to apply it for the entire recommended treatment period. Stopping too soon can cause your toenail infection to return and be more difficult to treat.
Don’t get a pedicure, wear nail polish, or apply cosmetic treatments to your toenails during Jublia treatment. Experts don’t know whether these products can affect how well Jublia works.
Store Jublia upright, tightly closed, and at room temperature. It’s important to keep the bottle away from heat and open flames. Jublia solution contains alcohol and is flammable.
There are ways to save on Jublia. If you’re eligible, a manufacturer savings card can help you access Jublia for as little as $0 per month.
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Does toenail fungus (onychomycosis) have you dreading sandal season? You’re not alone. Fungal nail infections affect about 1 in 7 people in the U.S. And toenails are more commonly impacted than fingernails. Thankfully, effective treatments exist for toenail fungus, such as Jublia.
Jublia (efinaconazole) is a prescription treatment for toenail fungus that’s applied directly to the nails and skin. It works better for these infections than over-the-counter (OTC) antifungals. And it can be a possible alternative to taking an oral medication, such as terbinafine tablets.
But, using it correctly helps you get the full benefit. Here’s what you should know about how to apply Jublia, plus a few more tips for success.
1. Here’s how to apply Jublia correctly
You should apply Jublia to clean, dry toenails. Wait at least 10 minutes after showering, bathing, or washing your feet before you apply it.
To get the most from your treatment, follow these steps when applying Jublia:
Remove the cap from the bottle.
Turn the bottle upside down, and hold it directly over the toenail you are treating. Then gently squeeze the bottle to moisten the applicator brush with one drop of Jublia.
Brush Jublia onto the affected toenail using the applicator brush. You should also brush Jublia onto the nail cuticle, folds of the skin on the sides of the toenail, and underneath the end of the nail.
For the big toenail, gently squeeze the bottle again to re-moisten the applicator brush and repeat the above steps.
Do not continually squeeze the bottle while applying Jublia, and don’t press or rub the brush firmly against the nail.
After applying Jublia to the affected toenails, let it dry completely before covering your feet with socks or shoes.
Put the cap back on the bottle and store the bottle upright.
Wash your hands with soap and water for at least 20 seconds after you’ve finished applying Jublia.
Good to know: You don’t need to remove Jublia from your nails using nail polish remover between applications. Just clean your feet using soap and water before each application.
2. Be sure to apply Jublia for the entire recommended treatment time
Jublia takes time to work. It’s recommended to apply it once a day for 48 weeks (about 11 months). You should keep applying Jublia for the full course of treatment, even if your toenail looks clear. Stopping treatment sooner can cause your toenail infection to come back and be more difficult to treat.
It’s best to apply Jublia around the same time every day. It might be helpful to insert it into a part of your daily routine to help you stay consistent. Pick a time of day or activity that’s easy to remember, like before bedtime or after a morning shower.
If you forget to apply Jublia at your usual time, apply it as soon as you remember. But if it’s almost time for your next application, skip the missed dose. Don’t apply extra solution to try to make up for missed doses.
If you’ve missed a lot of Jublia applications, reach out to your prescriber for guidance. They may recommend extending your treatment time or switching to a different medication.
3. Don’t use more Jublia than recommended
You should only apply Jublia once a day as directed. Applying extra solution or using it more than once a day won’t make it more effective. But it will waste medication and increase the risk of skin irritation or other side effects.
How long your bottle of Jublia will last depends on how many toenails you’re treating. A 4 mL Jublia bottle contains about 80 drops of medication. As discussed earlier, you’ll need to use one drop of medication per affected toenail each day. And if you’re treating the big toenail, you’ll need two drops per day. So if you’re just treating the big toe on one foot, a bottle of Jublia should last you about 40 days.
Compare options: Jublia (efinaconazole) is one of a few options for treating toenail fungal infections. Read about the available treatments for toenail fungus.
About nail fungus: Fungal nail infections are common and typically don’t resolve on their own without treatment. Read about nail fungus, complete with pictures of what it may look like.
Natural remedies: Some people prefer to try natural remedies for toenail fungus. However, these are typically less effective than conventional medication options.
To get the most out of every Jublia bottle, use only the recommended amount. Apply just enough solution to fully cover the affected toenail and the skin around it. Use gentle pressure when applying Jublia. And avoid squeezing the bottle at the same time that you’re brushing the solution onto your toenails.
4. You shouldn’t wear nail polish while using Jublia
Yes, toenail fungus can be unsightly. But it’s best to keep your toenails bare during Jublia treatment. Avoid getting pedicures, using nail polish, or covering your nails with any type of cosmetic product.
This is because we don’t have much information on whether nail polish and other cosmetics can interfere with how well Jublia works. What’s more, Jublia is likely to affect the appearance of nail polish, which can defeat the purpose of covering your toenail to begin with.
The good news is that you can still cover your toes with socks and shoes. Just be sure that your application of Jublia has fully dried first.
5. You should store Jublia at room temperature
You should store Jublia upright, in its original bottle, at room temperature (68°F to 77°F). Avoid storing it in places with excess heat and moisture, such as the bathroom. Make sure the cap is always screwed on tightly to keep the solution inside from spilling or evaporating.
You should also take steps to protect Jublia from extreme temperatures. The medication may not work as well if it freezes or overheats. This may be top of mind while traveling. Storing your Jublia bottle in the trunk of a car or in checked airline baggage could expose it to freezing or very hot temperatures.
There’s another reason that heat is a concern for Jublia storage — the solution contains alcohol. This means that it’s flammable. So don’t apply Jublia near candles, lanterns, or other open flames. Luckily, this isn’t the case once the solution fully dries after application. Your toenails won’t be flammable, and you can relax next to the campfire without worry.
How to save on Jublia
There are ways to save on the cost of Jublia, which is available as a brand-name medication. GoodRx can help you navigate between copay savings cards and patient assistance programs to save money on your prescription.
Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $0 for Jublia using a savings card from the manufacturer. But if Jublia isn’t covered, or if you’re uninsured, you may be able to pay as little as $65 for your prescription.
Save with patient assistance programs. If you’re uninsured or underinsured, you may be eligible for Jublia’s patient assistance program, which offers the medication free of charge.
Frequently asked questions
You’ll get the best results from Jublia by applying it correctly and using it for the full amount of time recommended. This means applying it once daily to clean, dry feet for a full 48 weeks.
It’s fine to wear socks after applying Jublia. But you should wait until the solution fully dries before putting them on. Keep in mind that socks that are too tight can damage your toenails and make them more prone to fungal infections. You should also wash your socks regularly in hot water or a sanitizing detergent to kill any fungal spores they pick up from your feet.
In clinical studies, Jublia treated the fungal infection in about 50% to 60% of people using it. But it only fully cleared the infection and returned nails to normal about 30% of the time. If Jublia doesn’t work for you, an oral antifungal (such as terbinafine) may be the next step.
You’ll get the best results from Jublia by applying it correctly and using it for the full amount of time recommended. This means applying it once daily to clean, dry feet for a full 48 weeks.
It’s fine to wear socks after applying Jublia. But you should wait until the solution fully dries before putting them on. Keep in mind that socks that are too tight can damage your toenails and make them more prone to fungal infections. You should also wash your socks regularly in hot water or a sanitizing detergent to kill any fungal spores they pick up from your feet.
In clinical studies, Jublia treated the fungal infection in about 50% to 60% of people using it. But it only fully cleared the infection and returned nails to normal about 30% of the time. If Jublia doesn’t work for you, an oral antifungal (such as terbinafine) may be the next step.
The bottom line
You should apply Jublia (efinaconazole) to clean, dry toenails once a day for 48 weeks (about 11 months). Be sure to use it for the entire recommended treatment time. Stopping too soon can cause your toenail infection to return and be more difficult to treat.
It’s not recommended to wear nail polish, get a pedicure, or apply cosmetic products to your nails while you’re using Jublia. Experts aren’t sure if this may impact the medication’s effectiveness. Store your Jublia bottle upright and at room temperature. Avoid exposing Jublia to open flames, as the solution is flammable.
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References
Axler, E., et al. (2024). Antifungal selection for the treatment of onychomycosis: Patient considerations and outcomes. Infection and Drug Resistance.
Bausch Health US. (2025). Jublia- efinaconazole solution [package insert].
Centers for Disease Control and Prevention. (2024). About handwashing.
Centers for Disease Control and Prevention. (2024). Clinical overview of ringworm and fungal nail infections.
Clinical Review Report: Efinaconazole (Jublia). (2019). Results. Canadian Agency for Drugs and Technologies in Health.
Del Rosso, J. Q. (2016). Application of nail polish during topical management of onychomycosis: Are data available to guide the clinician about what to tell their patients? Journal of Clinical and Aesthetic Dermatology.
InformedHealth.org. (2025). Overview: Nail fungus. Institute for Quality and Efficiency in Healthcare.
Leung, A. K. C., et al. (2020). Onychomycosis: An updated review. Inflammatory & Allergy Drug Targets.
MedlinePlus. (2017). Efinaconazole topical.
