Key takeaways
Paroxetine (Paxil) and duloxetine (Cymbalta) are both medications used to treat depression and anxiety, but they belong to different classes. Paroxetine is a selective serotonin reuptake inhibitor (SSRI), while duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI). Paroxetine is available in both immediate-release and extended-release forms, and it can also treat conditions like obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Duloxetine, on the other hand, is also used for treating nerve pain from diabetes, fibromyalgia, and long-term pain in muscles and joints. Both medications can cause side effects like nausea and sleepiness, but paroxetine is more likely to cause weight gain and sexual side effects. Duloxetine can affect liver health and blood pressure, making it less suitable for people who drink heavily or have liver problems. Both medications can cause withdrawal symptoms if stopped suddenly, so it's important to follow your provider's instructions when discontinuing them.
