Key takeaways
Olopatadine (Pataday) and epinastine (Elestat) are both antihistamine eye drops used to treat red and itchy eyes caused by allergies. However, there are some key differences between them. Olopatadine is available over-the-counter (OTC) in three different strengths, while epinastine requires a prescription. Olopatadine can be used once or twice daily depending on the strength, whereas epinastine is typically used twice a day. Both medications start working within minutes, with relief with epinastine lasting about 8 hours. On the other hand, the effects of olopatadine can last up to 24 hours. Both medications require you to remove contact lenses before use and wait 10 minutes before reinserting them. Common side effects of olopatadine include blurry vision and dry eye, while epinastine may cause a burning sensation, red eyes, and itchy eyes. They are both available as generics, but epinastine typically costs more than similar eye drops, including olopatadine.
