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Nuvigil vs. Vyvanse

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Armodafinil (Nuvigil) and Vyvanse (lisdexamfetamine) are both prescription medications, but they serve different purposes and belong to different drug classes. Armodafinil (Nuvigil) is a wakefulness-promoting agent used to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, or shift work disorder. Vyvanse (lisdexamfetamine), on the other hand, is a stimulant primarily used to treat attention deficit-hyperactivity disorder (ADHD) and moderate-to-severe binge eating disorder (BED) in adults. Armodafinil (Nuvigil) is a Schedule IV controlled substance, indicating a lower potential for abuse compared to Vyvanse (lisdexamfetamine), which is a Schedule II controlled substance with a higher risk of misuse and dependency. Both Armodafinil (Nuvigil) and Vyvanse (lisdexamfetamine) are available in a generic version. Both medications have side effects, but they differ; for example, armodafinil (Nuvigil) can cause fatigue and constipation, while Vyvanse (lisdexamfetamine) can lead to poor appetite and unintended weight loss. Additionally, Vyvanse (lisdexamfetamine) and armodafinil (Nuvigil) are not recommended for pregnant or breastfeeding women.

Armodafinil

(Nuvigil)

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Vyvanse

(lisdexamfetamine)

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Summary for Nuvigil

Prescription only

Armodafinil (Nuvigil) is used to improve wakefulness in adults who have extreme sleepiness due to narcolepsy, obstructive sleep apnea (OSA), or shift work disorder. It belongs to a drug class called wakefulness-promoting agents. Armodafinil (Nuvigil) is taken by mouth once a day. The exact dosage depends on the condition you have. Some side effects include headache, nausea, and dizziness. This medication is a controlled substance because it has a risk of misuse and dependence. Armodafinil (Nuvigil) is available in brand-name and generic versions.

Indications for Nuvigil

Pros and Cons for Nuvigil

Pros

Cons

Common Side Effects for Nuvigil

  • Headache (17%)
  • Nausea (7%)
  • Dizziness (5%)
  • Trouble sleeping (5%)
  • Anxiety (4%)
  • Diarrhea (4%)
  • Dry mouth (4%)

Warnings for Nuvigil

  • Serious allergic reactions
  • Serious skin reactions
  • Still feeling sleepy and risk of unsafe driving
  • Unusual changes in mood and behavior
  • Caution use in people with heart problems

Summary for Vyvanse

Prescription only

Vyvanse, the brand name for lisdexamfetamine, is a stimulant medication. It's used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It can also treat binge eating disorder (BED) in adults. Vyvanse (lisdexamfetamine) comes as capsules and chewable tablets. It's taken once per day in the morning. The dosage starts low and gets adjusted based on how you respond to the medication. Common side effects include trouble sleeping and loss of appetite. Vyvanse (lisdexamfetamine) is a controlled substance because it has a high risk of misuse and dependency.

Indications for Vyvanse

Pros and Cons for Vyvanse

Pros

  • A first-choice ADHD medication
  • Can help with ADHD for up to 14 hours with each dose
  • For binge eating disorder, can lower the number of binge-eating days per week by about one and a half days
  • Has a few options for people who have trouble swallowing pills whole (open the capsule or switch to chewable tablets)

Cons

  • Has a risk of misuse and dependency
  • A controlled medication, so there are special requirements for getting the prescription filled
  • Might need to take gradually lower doses before stopping to avoid withdrawal symptoms
  • Not the best choice for people with heart conditions

Common Side Effects for Vyvanse

ADHD

Binge eating disorder

  • Dry mouth (36%)
  • Trouble sleeping (20%)

Warnings for Vyvanse

  • Risk of misuse and addiction
  • Risks to people with serious heart problems
  • Higher blood pressure and faster heart rate
  • Strange thoughts or behavior
  • Slow growth in children
  • Problems with blood flow in the arms and legs, including Raynaud's phenomenon
  • Serotonin syndrome

Prices with our coupons for Nuvigil vs. Vyvanse

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Armodafinil30 tablets / 250mg
$34.91$568.00
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Lisdexamfetamine30 capsules / 30mg
$67.96$389.37
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