Key takeaways
Modafinil (Provigil) and bupropion (Wellbutrin SR, Wellbutrin XL, Forfivo XL) are both medications that can affect mood and alertness, but they belong to different medication classes and have distinct uses. Modafinil is a wakefulness-promoting agent primarily used to treat excessive sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. Bupropion, on the other hand, is an atypical antidepressant used to treat depression and seasonal affective disorder (SAD). While modafinil is taken once daily, bupropion can be taken in various forms, including immediate-release, sustained-release, and extended-release, with dosing ranging from once to three times daily. Modafinil is a controlled substance due to its potential for misuse and dependence, whereas bupropion is not. Common side effects of modafinil include headache and nausea, while bupropion may cause dry mouth and trouble sleeping. Modafinil can interact with medications like hormonal birth control and warfarin (Coumadin, Jantoven). Bupropion can increase the risk of seizures, especially if you have a history of seizures. Both medications require careful monitoring for mood changes.
