Key takeaways
Modafinil (Provigil) and Adderall (dextroamphetamine / amphetamine salts) are both medications used to treat narcolepsy, a condition that causes excessive daytime sleepiness. However, they belong to different medication classes and have distinct uses and effects. Modafinil is a wakefulness-promoting agent, while Adderall is a stimulant. Modafinil is also used for shift work disorder and obstructive sleep apnea. Adderall is primarily used for attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Modafinil is typically taken once daily, while Adderall may need to be taken multiple times a day due to its shorter duration of action. Adderall is also available in extended release forms like Adderall XR that may only need to be taken once daily. Both modafinil and Adderall are available as generics. They have different side effects and interactions; modafinil can cause headaches and nausea, and it may interact with hormonal birth control and other medications. Adderall can lead to trouble sleeping and loss of appetite. It can also interact with medications that affect serotonin levels, increasing the risk of serotonin syndrome. Both medications have a risk of misuse and dependence because they are controlled substances.
