Key takeaways
Mirtazapine (Remeron) and bupropion (Wellbutrin SR, Wellbutrin XL, Forfivo XL) are both atypical antidepressants used to treat depression. Mirtazapine is specifically approved for major depressive disorder (MDD) in adults, while bupropion is approved for depression and seasonal affective disorder (SAD). Mirtazapine is available as oral and orally disintegrating tablets, typically taken once daily at night, whereas bupropion comes in immediate-release, sustained-release, and extended-release forms, with dosing varying from once to three times daily. Mirtazapine is more likely to cause weight gain and sleepiness, while bupropion is less likely to cause weight gain and may lead to trouble sleeping if taken later in the day. Bupropion is not recommended for those with a history of seizures or eating disorders, and it can increase the risk of seizures, especially if taken in high doses or with alcohol. Both medications can cause dry mouth and dizziness. Additionally, both medications can interact with medications like monoamine oxidase inhibitors (MAOIs), other antidepressants, and alcohol.
