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Methyltestosterone vs. Androderm

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Methyltestosterone (Methitest) and Androderm (testosterone patch) are both testosterone replacement therapies, but they have some key differences. Methyltestosterone is taken orally and is used to treat low testosterone in males, delayed puberty in boys, and breast cancer in females. It is available in a generic form, but it can cause serious liver side effects. Androderm, on the other hand, is a transdermal patch applied to the skin once a day to treat low testosterone in adult males. It has been discontinued in the United States, so you would need to look for alternative treatments. Androderm can cause skin irritation and requires rotating application sites to avoid rashes. Both medications are controlled substances due to the risk of misuse and dependency, but Androderm has a lower risk of accidentally exposing others to testosterone compared to gels.

Methyltestosterone

(Methitest)

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Androderm

(testosterone patch)

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Summary for Methyltestosterone

Prescription only

Methyltestosterone (Methitest) is a pill form of testosterone used for testosterone replacement therapy (TRT) in males with low testosterone levels. It's also used to treat females with breast cancer that has spread to other parts of the body. The medication comes as a tablet or capsule and is typically taken by mouth once a day. Your dosage will depend on your condition and how you respond to treatment. Possible side effects include nausea, acne, and headaches.

Indications for Methyltestosterone

Males

Females

Pros and Cons for Methyltestosterone

Pros

  • Is a pill taken by mouth
  • Restores healthy testosterone levels in men
  • Supports male development during puberty

Cons

  • Risk of liver problems with long-term use
  • Potential for serious heart problems and blood clots
  • Risk of misuse and dependence since it's a controlled substance

Common Side Effects for Methyltestosterone

Males

  • Breast enlargement
  • Acne

Females

  • Deeper voice
  • Acne
  • Missed or irregular menstrual periods
  • Increased facial and body hair

Warnings for Methyltestosterone

  • Liver problems
  • Risk of blood clots, including heart attack or stroke
  • Potential for misuse, dependency, and addiction
  • Swelling in the legs or arms (edema)
  • High calcium in the blood
  • Fast bone maturation in children

Summary for Androderm

Prescription only

Androderm (testosterone patch) is a testosterone replacement therapy that acts like the natural sex hormone testosterone. It raises testosterone levels in adult males who are diagnosed with low testosterone, also known as hypogonadism. Androderm (testosterone patch) is a patch that's applied to your skin once a day. Some common effects of this medication include skin irritation, itching, and burning.

Please note: Androderm (testosterone patch) has been discontinued and is no longer available in the United States. Talk to your primary care provider about alternative testosterone replacement therapies available to treat low testosterone.

Indications for Androderm

Pros and Cons for Androderm

Pros

  • Compared to testosterone gel, there’s a lower risk of accidentally exposing others to testosterone
  • Doesn't need to be removed during sex or while showering or bathing
  • Applied to your skin
  • Applied once a day

Cons

  • Can cause skin irritation
  • Need to remember to rotate application sites every night
  • Heavy exercise or sweating too much might cause the patch to loosen or fall off
  • Need to wait 3 hours before you can shower, swim, or bathe

Common Side Effects for Androderm

  • Application site itchiness (17%)
  • Application site blisters (6%)
  • Back pain (6%)

Warnings for Androderm

  • Higher red blood cell count and high risk of heart attack or stroke
  • Blood clots
  • Potential for misuse, dependency, and addiction
  • Worsening symptoms of enlarged prostate and prostate cancer
  • Liver problems
  • Low sperm count
  • Swelling in the legs or arms (edema)
  • Breathing problems during sleep (sleep apnea)
  • High calcium in the blood

Prices with our coupons for Methyltestosterone vs. Androderm

Price Card Drug Icon
Methyltestosterone30 capsules / 10mg
$571.60$2,520.09
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Androderm1 carton / 60 patches of 2mg per day
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