Key takeaways
Meloxicam and naproxen (Naprosyn, EC-Naprosyn) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation associated with conditions like rheumatoid arthritis and osteoarthritis. However, they differ in several ways. Meloxicam is available in various forms, including capsules, tablets, oral suspension, and an injection (administered only by a healthcare professional), while naproxen is available as tablets and oral liquid suspension. Meloxicam is typically taken once daily, whereas naproxen is usually taken two to three times per day. Meloxicam is more selective for cyclooxygenase (COX)-2, which may result in fewer stomach and kidney side effects compared to naproxen, which blocks both COX-1 and COX-2. Common side effects of meloxicam and naproxen include diarrhea, heartburn, and upset stomach. Both medications can increase the risk of stomach bleeding, especially when taken with alcohol or other NSAIDs. Both medications are available as a lower-cost generics, and naproxen also has an over-the-counter form (Aleve).
