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Lantus vs. Actos

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lantus (insulin glargine) and Actos (pioglitazone) are both used to manage diabetes, but they work in different ways and are used for different types of diabetes. Lantus is a long-acting insulin injected under the skin, typically once daily, to help control blood sugar levels in both Type 1 and Type 2 diabetes. In contrast, Actos is an oral medication taken once daily that helps your body use insulin more effectively, but it is only used for Type 2 diabetes. Lantus can cause low blood sugar levels and weight gain, while Actos may take several weeks to show its full effect and can cause fluid build-up, weight gain, and increased risk of bladder cancer and bone fractures. Additionally, Actos is not suitable for people with heart failure or bladder cancer, whereas Lantus requires careful monitoring to avoid dangerously low blood sugar levels. Both medications require a prescription and have specific storage and usage instructions to ensure they work effectively.

Lantus

(insulin glargine)

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Pioglitazone

(Actos)

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Summary for Lantus

Prescription only

Lantus (insulin glargine) is a type of long-acting insulin. It's used to help manage blood sugar levels in people with Type 1 diabetes or Type 2 diabetes. Lantus (insulin glargine) is injected under the skin once daily. Your dose will depend on a few things, such as the type of diabetes you have and your blood sugar levels. This medication comes in a vial (Lantus) as well as in a prefilled insulin pen (Lantus Solostar). Some side effects include upper respiratory tract infections. It can also cause redness and swelling at the injection site.

Indications for Lantus

Pros and Cons for Lantus

Pros

  • Helps keep your blood sugar controlled for about 24 hours
  • Injected once daily
  • Approved for both adults and children
  • Available as a vial and prefilled pen

Cons

  • Given as an injection under the skin
  • Has a risk of causing dangerously low blood sugar
  • Might cause weight gain
  • Can't be mixed with other insulins within the same syringe

Common Side Effects for Lantus

Type 1 diabetes

Type 2 diabetes

  • Upper respiratory tract infection (11%)
  • Other infection (10%)
  • Eye problem (6%)

Warnings for Lantus

  • Risk of infection from sharing pens and needles
  • Risk of changes to blood sugar levels with changes to your insulin routine
  • Low blood sugar (hypoglycemia)
  • Low potassium levels
  • Swelling and risk of heart failure when using with certain diabetes medications
  • Severe allergic reaction

Summary for Actos

Prescription only

Pioglitazone (Actos) is an oral medication used to treat Type 2 diabetes in adults, along with diet and exercise. It's a thiazolidinedione, which works by helping your body respond better to insulin. This medication is taken by mouth once a day and is available in both brand and generic forms. Side effects include headache, swelling in the body, and weight gain. There's also a serious warning that it can cause or worsen heart failure.

Indications for Actos

Pros and Cons for Actos

Pros

  • Only taken once a day
  • Rarely causes dangerously low blood sugar when taken by itself
  • Can be taken with or without food

Cons

  • Can cause fluid buildup in the body
  • Not safe for people with moderate to severe heart failure
  • Not a good choice for people with bladder cancer

Common Side Effects for Actos

  • Swelling (27%)
  • Upper respiratory tract infection (13%)
  • Headache (9%)
  • Heart failure (8%)
  • Sinus infection (6%)
  • Pain in the arms and legs (6%)

Side effects above are for pioglitazone (Actos) taken alone. These might differ if it's taken with other medications.

Warnings for Actos

  • Heart failure and swelling
  • Low blood sugar (when used with other medications)
  • Liver problems
  • Bladder cancer
  • Risk of bone fractures
  • Eye problems

Prices with our coupons for Lantus vs. Actos

Price Card Drug Icon
Lantus1 carton / 5 solostar pens of 3ml
$35.00-
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Pioglitazone30 tablets / 30mg
$12.52$19.06
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