Key takeaways
Lamotrigine (Lamictal) and lithium (Lithobid) are both used to treat bipolar disorder, but they have different uses and side effects. Lamotrigine is an antiepileptic that can also treat seizures, while lithium is an antimanic specifically for bipolar disorder and manic episodes. Lamotrigine is available in various forms, including chewable and extended-release tablets, and it can cause serious skin reactions like rash. Lithium, on the other hand, is available as instant-release pills, oral liquid, and extended-release tablets, and it requires regular blood tests to prevent toxicity. Lamotrigine can cause dizziness and headaches, while lithium can lead to shakiness, thirst, and nausea. Both medications are available as lower-cost generics, but lithium has more interactions with other medications and requires careful monitoring of fluid and salt intake.
