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Lamictal vs. Abilify

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lamotrigine (Lamictal) and aripiprazole (Abilify) are both prescription medications, but they are used for different conditions and belong to different drug classes. Lamotrigine is an antiepileptic used to treat seizures and bipolar I disorder, while aripiprazole is an atypical antipsychotic used for schizophrenia, bipolar I disorder, and as an add-on for depression. Lamotrigine is available in various forms, including immediate-release and extended-release tablets, and can cause serious skin reactions like rash. Aripiprazole, on the other hand, is available in tablets, solutions, and orally disintegrating tablets, and can cause side effects like movement problems and sleep issues. While both medications can cause dizziness and have serious side effects, aripiprazole is more likely to cause weight gain and high blood sugar. Lamotrigine requires careful dose adjustments to avoid severe skin reactions, whereas aripiprazole can take several weeks to show full effects and may cause impulse-control problems. Both medications are available in generic forms.

Lamotrigine

(Lamictal)

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Aripiprazole

(Abilify)

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Summary for Lamictal

Prescription only

Lamotrigine (Lamictal) is an antiepileptic medication. The immediate-release version can treat different types of seizures as well as bipolar 1 disorder. But the extended-release version is only for seizures. Your dose depends on your age, the other medications you take, and what problem you're treating. Side effects can include dizziness, headache, and serious skin reactions. It can also cause withdrawal symptoms like seizures if you stop taking it suddenly.

Indications for Lamictal

Pros and Cons for Lamictal

Pros

  • Available in different formulations (regular immediate-release tablets, chewable tablets, quick-dissolving tablets, and extended-release tablets)
  • Can use a starter kit to help with dosing when you first start the medication
  • Approved for children of certain ages with seizures (age depends on formulation)

Cons

Common Side Effects for Lamictal

Immediate release:

  • Dizziness (38%)
  • Headache (29%)
  • Double vision (28%)
  • Problems with coordination (22%)
  • Nausea (19%)
  • Blurry vision (16%)
  • Sleepiness (14%)
  • Runny or stuffy nose (14%)
  • Sore throat (10%)
  • Rash (10%)

Extended release:

  • Dizziness (14%)
  • Nausea (7%)
  • Vomiting (6%)
  • Tremor (6%)
  • Feeling tired (6%)
  • Double vision (5%)
  • Diarrhea (5%)

Warnings for Lamictal

  • Serious skin rashes
  • Serious allergic reaction
  • Overactive immune response to the medication
  • Irregular heartbeat
  • Risk of suicidal thoughts and behavior
  • Meningitis (inflammation in the brain)
  • Withdrawal seizures
  • Possible eye problems
  • Interactions with other medications

Summary for Abilify

Prescription only

Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

  • Can make you feel restless
  • Risk of movement problems that can be permanent
  • Can raise blood sugar and cholesterol
  • Can take several weeks to see the full effects

Common Side Effects for Abilify

  • Headache (27%)
  • Agitation (19%)
  • Trouble sleeping (18%)
  • Anxiety (17%)
  • Nausea (15%)
  • Vomiting (11%)
  • Constipation (11%)
  • Dizziness (10%)
  • Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.

Warnings for Abilify

  • Higher risk of death in older adults with dementia-related psychosis
  • Neuroleptic malignant syndrome
  • High blood sugar, high cholesterol, and weight gain
  • Difficulty controlling movements
  • Changes in blood pressure and higher risk of falls
  • Risk of infection (from low white blood cell count)
  • Difficulty concentrating and extreme sleepiness
  • Seizures
  • Impulse-control problems

Prices with our coupons for Lamictal vs. Abilify

Price Card Drug Icon
Lamotrigine30 tablets / 100mg
$9.00$9.00
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Aripiprazole30 tablets / 5mg
$12.66$439.57
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