Key takeaways
Ibuprofen (Advil, Motrin) and hydrocodone / acetaminophen (Norco) are pain medications. Ibuprofen is an nonsteroidal anti-inflammatory drugs (NSAID) and Norco is an opioid. Ibuprofen is often a first-choice medication for mild-to-moderate pain, as most forms of it are available over the counter. Ibuprofen is usually tried before Norco, which is available only by prescription. Common Ibuprofen side effects include nausea, heartburn, and stomach pain. More seriously, it can cause kidney damage, bleeding, and heart problems, but these effects are rare. Common Norco side effects include nausea, constipation, and drowsiness. More seriously, Norco can lead to misuse, breathing problems, and overdose. It’s a controlled substance, but ibuprofen isn’t. Taking Norco and ibuprofen as prescribed can minimize these risks. Norco is a brand-name of hydrocodone / acetaminophen that’s no longer available, but we’ll use the name here because it’s well-known.
