Key takeaways
Fluphenazine (generic, formerly known as Prolixin) and Thioridazine (generic, formerly known as Mellaril) are both typical antipsychotics, but they have some key differences. Fluphenazine is used to treat psychotic disorders and is available in both short-acting and long-acting forms, which can be taken orally or via injection. Thioridazine, on the other hand, is specifically used for schizophrenia when other antipsychotic medications haven't worked or caused intolerable side effects. Thioridazine is only available in oral form and is not a first-choice treatment due to its risk of causing dangerous heart rhythm changes. While both medications can cause movement problems and drowsiness, Thioridazine is less likely to cause muscle movement issues compared to other antipsychotics. Oral forms of both medications need to be taken multiple times per day. Both medications can cause serious side effects like neuroleptic malignant syndrome and should not be used in older adults with dementia-related psychosis. Additionally, Thioridazine has more restrictions due to its potential to interact with other medications and cause life-threatening heart issues.
