Skip to main content

Compare
Fiorinal vs. Relpax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Butalbital/aspirin/caffeine (formerly Fiornal) nd Relpax (eletriptan) are both used to treat headaches, but they work in different ways and are used for different types of headaches. Fiorinal is a combination medication that includes a barbiturate, a nonsteroidal anti-inflammatory drug (NSAID), and caffeine, and it's used to treat tension headaches. It is a Schedule III controlled substance due to the risk of misuse and dependence. On the other hand, Relpax is a triptan used to treat migraine attacks with or without aura. It works by attaching to serotonin receptors in the brain to relieve migraine pain. Unlike Fiorinal, Relpax is not a controlled substance and is considered a first-choice treatment for migraines. Fiorinal is taken every 4 hours as needed, while Relpax is taken at the first sign of a migraine and can be repeated after 2 hours if needed. Both medications are available in generic forms, making them more affordable options. However, Fiorinal is not recommended during pregnancy or breastfeeding, whereas the safety of Relpax during pregnancy is not fully established and should be discussed with a healthcare provider.

Fiorinal

 

Get free coupons

Eletriptan

(Relpax)

Get free coupons

Summary for Fiorinal

Prescription only

Fiorinal is a combination medication that contains three active ingredients: butalbital (a barbiturate), aspirin (an NSAID), and caffeine (an adenosine antagonist). It's used to treat symptoms of tension headaches in adults. The brand name Fiorinal has been discontinued, but there are still lower-cost generic pills available. The medication is taken by mouth every 4 hours. The most common side effects are sleepiness and dizziness. This medication is a schedule III controlled substance because it has a risk of misuse and dependence.

Indications for Fiorinal

Pros and Cons for Fiorinal

Pros

  • Works well to treat tension headaches
  • Combines three medications into a single pill to relieve headache pain in different ways
  • Available as a lower-cost generic

Cons

  • Not recommended as a first-choice option for headaches because of the risk of rebound headaches
  • A controlled medication that can be habit-forming
  • Can cause bothersome withdrawal symptoms if you suddenly stop the medication after taking it for a long time
  • Hasn't been studied in children

Common Side Effects for Fiorinal

  • Sleepiness
  • Dizziness

Warnings for Fiorinal

  • Stomach bleeding and ulcers
  • Kidney problems
  • Reye's syndrome in children
  • Difficulty concentrating and extreme sleepiness
  • Potential for misuse, dependence, and withdrawal
  • Severe allergic reactions and skin reactions

Summary for Relpax

Prescription only

Eletriptan, also known by its brand name Relpax, is a triptan that's a first-choice treatment option for adults who have migraine attacks with or without aura. This medication is available as a tablet that's taken by mouth at the first sign of a migraine attack. The dosage can be repeated 2 hours later if the migraine comes back or doesn't go away. Side effects include making you sleepy and dizzy. Eletriptan (Relpax) is available as a lower-cost generic.

Indications for Relpax

Pros and Cons for Relpax

Pros

Cons

  • Only available as a tablet that's swallowed whole
  • Not recommended for people with severe liver damage
  • Not known if it's safe or works well for children
  • Not used for preventing migraines or treating other types of headaches

Common Side Effects for Relpax

  • Dizziness (up to 6%)
  • Sleepiness (up to 6%)
  • Nausea (up to 5%)
  • Body weakness (up to 5%)
  • "Pins and needles" feeling in the arms or legs (3%)

Warnings for Relpax

  • Heart problems and high blood pressure
  • Stroke or other brain injury
  • Extreme narrowing of blood vessels
  • Worsened headaches if eletriptan (Relpax) is taken too often
  • Serotonin syndrome

Prices with our coupons for Fiorinal vs. Relpax

Price Card Drug Icon
Butalbital/Aspirin/Caffeine30 tablets / 50mg/325mg/40mg
--
Get free coupons
More Information
Price Card Drug Icon
Eletriptan12 tablets / 40mg
$36.13$346.58
Get free coupons
More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.