Key takeaways
Fentanyl (Duragesic) and oxycodone (Roxicodone) are both opioids used to treat pain, but they have some key differences. Fentanyl is available as a transdermal patch and is used for severe, long-term pain in people who are already opioid-tolerant. It works by releasing medication through your skin over 72 hours. Fentanyl patches are not recommended for short-term pain control or for those who are not opioid-tolerant. Oxycodone, on the other hand, is an immediate-release medication available in forms like tablets, capsules, and liquid, and is used for pain that isn't relieved by non-opioid medications. It starts working within 10 to 30 minutes and lasts for about 3 to 6 hours. It is typically taken every 4 to 6 hours as needed for pain. Both medications have a high risk of misuse and dependence, which is why they are both considered controlled substances. Both medications have a high risk of misuse, dependency, and addiction, but Fentanyl requires special monitoring and training for healthcare providers due to its higher risk of life-threatening side effects.
