Key takeaways
Adapalene/benzoyl peroxide (Epiduo, Epiduo Forte) and benzoyl peroxide (Advanced Acne Wash, PanOxyl, and others) are both topical medications used to treat acne. They share the active ingredient benzoyl peroxide, which acts as an antiseptic to kill acne-causing bacteria. However there are some differences. Adapalene/benzoyl peroxide is a combination medication that also includes adapalene, a retinoid that helps prevent clogged pores by promoting skin cell turnover. This combination is available by prescription only, while benzoyl peroxide can be purchased over-the-counter in various forms and strengths. Adapalene/benzoyl peroxide is typically applied once daily, whereas benzoyl peroxide can be used up to three times a day, depending on the form and your provider's instructions. Common side effects of both medications include skin irritation and dryness, but adapalene/benzoyl peroxide may also cause skin scaling. Both medications can make your skin more sensitive to sunlight and can bleach hair and fabrics. If you have sensitive skin, benzoyl peroxide might not be the best option for you, and you should consult your provider before use.
