Key takeaways
Enbrel (etanercept) and Simponi (golimumab) are both injectable medications used to treat autoimmune conditions, but they have some key differences. Enbrel is a biologic DMARD available only as a brand-name product and has several biosimilars, while Simponi is also a brand-name medication but comes in two forms: Simponi for subcutaneous injection and Simponi Aria for intravenous infusion. Enbrel is typically injected once a week, whereas Simponi is injected once a month, making Simponi more convenient for some people. Enbrel is used for conditions like rheumatoid arthritis, plaque psoriasis, and childhood arthritis, while Simponi is also approved for ulcerative colitis. Both medications can raise the risk of serious infections and certain cancers, but Simponi has additional warnings for lupus-like syndrome and low blood cell counts. Enbrel can be stored at room temperature for up to 14 days, whereas Simponi can be stored at room temperature for up to 30 days.
