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Cleocin vs. Erythromycin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cleocin (clindamycin) and erythromycin are both antibiotics, but they are used to treat different types of infections and come in different forms. Cleocin (clindamycin) is a lincosamide antibiotic used as a vaginal suppository to treat bacterial vaginosis. It is only available as a brand-name medication, which can make it expensive. On the other hand, erythromycin is a macrolide antibiotic used as an eye ointment to treat and prevent bacterial eye infections, including pink eye in newborns. Erythromycin is available as a lower-cost generic medication. Cleocin (clindamycin) is typically used once daily for three days, while erythromycin eye ointment may need to be applied up to six times a day, depending on the severity of the infection. Cleocin (clindamycin) can cause local side effects like vaginal irritation and yeast infections, whereas erythromycin eye ointment can cause mild eye irritations and redness. Additionally, Cleocin (clindamycin) should not be used if you have certain bowel problems, while erythromycin eye ointment should not be used if you have a viral eye infection.

Cleocin

(clindamycin)

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Erythromycin

 

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Summary for Cleocin

Prescription only

Cleocin (clindamycin) vaginal ovule is an antibiotic suppository that treats bacterial vaginosis (BV), a type of vaginal infection. This medication can be prescribed for adults or adolescent females who've started their menstrual periods. But it's not approved for people who are pregnant. Cleocin (clindamycin) vaginal suppository is inserted vaginally once daily, typically at bedtime, for 3 days. Side effects aren't common, but can include vaginal discomfort, such as irritation and pain.

Indications for Cleocin

Pros and Cons for Cleocin

Pros

  • Only used once a day
  • Typically only used for 3 days
  • Applicator can be washed and reused for each insertion
  • Can be inserted without using an applicator

Cons

  • Vaginal application can be uncomfortable for some people
  • Might cause vaginal yeast infections
  • Can't use condoms, diaphragms, or tampons during and up to 3 days after treatment
  • Recommended to use at bedtime to prevent medication from leaking

Common Side Effects for Cleocin

Warnings for Cleocin

  • Severe diarrhea
  • Vaginal yeast infections
  • Damage to vaginal contraceptives

Summary for Erythromycin

Prescription only

Erythromycin is an antibiotic that's used to treat a variety of infections caused by bacteria, including certain skin and respiratory infections. The dosage depends on the specific infection you're using it for. The most common side effects are related to the stomach, like nausea, vomiting, and diarrhea. Erythromycin comes in two forms that are taken by mouth: oral tablets and an oral suspension.

Indications for Erythromycin

Pros and Cons for Erythromycin

Pros

  • Treats many types of infections
  • Available as a lower-cost generic
  • EES is available as an oral tablet or oral suspension

Cons

  • Commonly causes nausea, diarrhea, vomiting, and stomach upset
  • Interacts with many medications
  • Has to be taken multiple times a day

Common Side Effects for Erythromycin

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Anorexia

Warnings for Erythromycin

  • Liver damage
  • Life-threatening changes in your heart rhythm (QT prolongation)
  • Syphilis in infants
  • Severe diarrhea
  • Interactions with other medications
  • Worsening of myasthenia gravis
  • Intestinal blockage in babies

Prices with our coupons for Cleocin vs. Erythromycin

Price Card Drug Icon
Clindamycin30 capsules / 300mg
$16.95-
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Erythromycin1 tube / 3.5g of 0.5%
$11.79$11.98
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