Key takeaways
Celecoxib (brand name Celebrex) and ibuprofen (brand names Advil, Motrin) are both nonsteroidal anti-inflammatory medications (NSAIDs) used to relieve pain and inflammation. They are similar in that they both treat conditions like osteoarthritis and rheumatoid arthritis, though ibuprofen is also commonly used for fever and minor aches. Celecoxib is a COX-2 selective NSAID, which means it specifically targets the COX-2 enzyme, potentially causing fewer stomach issues compared to ibuprofen, which blocks both COX-1 and COX-2 enzymes. Celecoxib is available by prescription only, while ibuprofen can be purchased over-the-counter or by prescription, depending on the strength. Celecoxib is typically taken once or twice a day, whereas ibuprofen is taken every 4 to 8 hours. Common side effects of celecoxib include headache and indigestion, while ibuprofen may cause nausea and heartburn. Both medications carry risks of heart attack, stroke, and stomach bleeding, but celecoxib may have a lower risk of stomach issues due to its selective action.
