Key takeaways
Sotalol (Betapace) and amiodarone (Pacerone) are both antiarrhythmic medications used to treat heart rhythm problems. They are similar in that they can both be used to manage ventricular arrhythmias, but amiodarone is also used off-label for atrial fibrillation, while sotalol is FDA-approved for preventing atrial fibrillation or atrial flutter. Sotalol is typically started in the hospital, where you'll stay for at least 3 days to be sure you don't experience any serious side effects. Sotalol is available in both tablet and liquid forms and is typically taken twice a day, whereas amiodarone is available as a tablet and can be taken once daily. Both medications are available as a lower-cost generic. Common side effects of sotalol include tiredness and dizziness, while amiodarone can cause nausea and sensitivity to the sun. Sotalol can interact with antacids and some blood pressure medications, while amiodarone can interact with grapefruit and many other medications.
