Key takeaways
Azithromycin (Zithromax) and ciprofloxacin (Cipro) are both antibiotics used to treat bacterial infections, including sinus infections and pneumonia. However, they belong to different medication classes. Azithromycin is a macrolide antibiotic, while ciprofloxacin is a fluoroquinolone antibiotic. Azithromycin is typically taken once daily for 3 to 5 days, whereas ciprofloxacin is usually taken twice daily. Both medications are available as a generic and both are availible as tablet, oral liquid, and injection forms. Common side effects of both medications include diarrhea, nausea, and stomach pain. Ciprofloxacin has more serious potential side effects, such as tendon rupture and nerve damage, and interacts with many medications, including metformin and warfarin. Azithromycin can cause QT prolongation, especially when taken with certain medications, and may not be suitable for people with severe liver problems.
