Key takeaways
Lorazepam (Ativan) and chlordiazepoxide (Librium) are both benzodiazepines used for short-term treatment of anxiety, but they have some differences. Lorazepam is available as an oral tablet, liquid, and injectable, while chlordiazepoxide is only available as an oral capsule. Lorazepam can also be used to control seizures and ease surgery-related anxiety, whereas chlordiazepoxide is specifically used to prevent alcohol withdrawal symptoms. Lorazepam tends to work faster, with effects starting within 30 minutes to 2 hours. Chlordiazepoxide can take up to 4 hours to reach maximum levels in your blood. Both medications have a risk of addiction and withdrawal symptoms if stopped suddenly, but chlordiazepoxide stays in your system longer. It can take chlordiazepoxide over 10 days to fully leave your body. Additionally, lorazepam is available in both brand and lower-cost generic forms, while chlordiazepoxide is only available as a generic. Both medications should be used with caution, especially in older adults and those with a history of substance misuse.
