Key takeaways
Hydroxyzine (Vistaril) and clonazepam (Klonopin) are both medications that treat anxiety. Hydroxyzine is an antihistamine that can also treat allergy-related symptoms. It's typically only used for short-term anxiety treatment and isn't usually a first-choice treatment option. Clonazepam is a benzodiazepine that's also used to treat seizures. It works by increasing the levels of a chemical called GABA, which helps calm the mind and body. Clonazepam is a controlled substance due to its risk of dependence and misuse. Both medications can cause drowsiness and should not be mixed with alcohol.
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