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Klonopin vs. Unisom

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Clonazepam (Klonopin) and doxylamine (Unisom SleepTabs) are used for different purposes and belong to different medication classes. Clonazepam is a prescription-only benzodiazepine used for treating seizures and panic disorder, while doxylamine is an over-the-counter antihistamine used to help with sleep problems. Clonazepam is taken two to three times a day and can be habit-forming, so it’s not usually recommended for long-term use. In contrast, doxylamine is taken once nightly, about 30 minutes before bedtime. Clonazepam can cause side effects like drowsiness, dizziness, and poor movement control, whereas doxylamine commonly causes next-day sleepiness and dizziness. Clonazepam is a controlled substance due to its potential for misuse and dependence, while doxylamine is not a controlled medication and is available over the counter.

Clonazepam

(Klonopin)

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Doxylamine

(Unisom SleepTabs)

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Summary for Klonopin

Prescription only

Clonazepam (Klonopin) is a benzodiazepine. It's approved to treat seizures in adults and children, and panic disorder in adults only. Clonazepam (Klonopin) is taken by mouth, typically two or three times a day. It's also available as orally disintegrating tablets (ODTs) for people who have trouble swallowing. Some common side effects of this medication include drowsiness, dizziness, and poor movement control. Before stopping clonazepam (Klonopin), speak with your prescriber to come up with a plan to lower your dose slowly over time to avoid withdrawal symptoms.

Indications for Klonopin

Pros and Cons for Klonopin

Pros

Cons

  • Taken 2 to 3 times daily
  • Can be habit-forming, so isn't typically used for long-term treatment
  • Can cause memory problems, drowsiness, dizziness, and confusion
  • Might not work as well for seizure control over time

Common Side Effects for Klonopin

Seizures:

  • Drowsiness (50%)
  • Poor movement control, clumsiness (30%)
  • Behavior problems (25%)

Panic Disorder:

  • Drowsiness (up to 50%)
  • Dizziness (up to 12%)
  • Runny nose, sore throat, and other symptoms of a respiratory infection (up to 10%)
  • Extreme tiredness (up to 9%)
  • Poor movement control, clumsiness (up to 9%)
  • Depression (up to 8%)

Warnings for Klonopin

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Suicidal thoughts or behaviors
  • Effect on driving and concentration
  • Harm to babies
  • Worsening of seizures

Summary for Unisom

Over-the-counter

Doxylamine succinate (Unisom SleepTabs) is an over-the-counter antihistamine that can be taken by adults and children ages 12 years and older who are having trouble falling asleep. It's a sleep aid that works by blocking certain chemicals (histamine) in your body. Doxylamine (Unisom SleepTabs) is taken by mouth once a day, about 30 minutes before bedtime. The most common side effect of this medication is next-day sleepiness.

Indications for Unisom

Pros and Cons for Unisom

Pros

  • Works well to help you fall asleep
  • Available over the counter and as a lower-cost generic
  • Starts to work quickly (within 1 hour)
  • Can be used in children as young as 12 years old

Cons

Common Side Effects for Unisom

Warnings for Unisom

  • Extreme sleepiness
  • Worsening of medical conditions
  • Accidental overdose

Prices with our coupons for Klonopin vs. Unisom

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Clonazepam30 tablets / 0.5mg
$10.67-
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Doxylamine30 tablets / 25mg
$13.18-
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