Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Ajovy vs. Emgality

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ajovy (fremanezumab) and Emgality (galcanezumab) are both medications used to prevent migraines, but they have some differences. Ajovy is a CGRP receptor blocker, while Emgality is a monoclonal antibody that blocks the CGRP ligand. Ajovy is available only as a brand-name medication and can be injected once a month or once every three months. Emgality, also a brand-name medication, is injected once monthly. Ajovy is used solely for migraine prevention, while Emgality can also treat episodic cluster headaches. Common side effects for Ajovy include injection-site reactions like pain and swelling, while Emgality can cause injection-site reactions, sore throat, and back pain. Both medications need to be stored in the refrigerator but can be kept at room temperature for up to 7 days.

  • Ajovy (fremanezumab)
    Emgality (galcanezumab)
  • Ajovy (fremanezumab)
    Emgality (galcanezumab)

  • Summary of Ajovy vs. Emgality

    Summary for CGRP receptor blocker
    Prescription only

    Ajovy (fremanezumab or fremanezumab-vfrm) is an injection under the skin that helps prevent migraines in adults. This medication is convenient because it only needs to be used once every month or once every 3 months. The only observed side effects in clinical studies were injection-site reactions (e.g., pain, swelling, redness). Ajovy (fremanezumab) is available as a prefilled autoinjector pen and a prefilled syringe. It's currently only available as a brand-name medication; there's no generic yet.

    Summary for CGRP antagonist
    Prescription only

    Emgality (galcanezumab or galcanezumab-gnlm) is an injectable medication that can help prevent migraine attacks in adults. It can also help treat cluster headaches in adults. This medication is a monoclonal antibody that works as a CGRP antagonist. It blocks the CGRP protein in the brain that can cause migraine and headache pain. Emgality (galcanezumab) comes as a prefilled pen and syringe. You inject one dose of the medication under the skin monthly. Some common side effects include pain, itching, and redness at the injection site.

  • Indications of Ajovy vs. Emgality

    Indications for
    •Prevention of migraines in adults
    Indications for
    •Prevention of migraines in adults
    •Treatment of episodic (occasional) cluster headaches in adults

  • Pros and Cons of Ajovy vs. Emgality

    Pros and Const for CGRP receptor blocker
    Pros
    •Taken only once per month or once every 3 months
    •Can store at room temperature for up to 7 days, if needed
    •Available as a prefilled syringe and a prefilled autoinjector
    •Manufacturer offers a savings program for certain people
    Cons
    •Might be difficult for some people to use properly
    •Only used for preventing migraines (not for treating a migraine attack)
    •Available as a brand-name medication only
    •Hasn't been studied in children younger than 18 years old
    Pros and Const for CGRP antagonist
    Pros
    •Only needs to be given once a month
    •Good option for people who have a hard time taking medications by mouth
    •Generally well tolerated
    Cons
    •Not a good option for people who don't like needles
    •Need to store in a refrigerator
    •Not known if the medication works well or is safe in children, during pregnancy, or while breastfeeding

  • Common Side Effects of Ajovy vs. Emgality

    Common Side Effects for
    •Pain, swelling, or redness at the injection site (43-45%)
    Common Side Effects for
    •Pain, itching, warmth, and other injection site reactions (18%)

  • Warnings of Ajovy vs. Emgality

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Serious allergic reactions
    •High blood pressure
    •Raynaud's phenomenon

  • Prices with our coupons for Ajovy vs. Emgality

    Learn more about Ajovy
    Learn more about Emgality

Compare other Migraine drugs

Aimovig vs AjovyAjovy vs EmgalityReyvow vs AjovyUbrelvy vs AjovyAimovig vs BotoxAimovig vs EmgalityEffexor vs FioricetElavil vs FioricetEmgality vs FioricetEmgality vs FrovaEmgality vs MaxaltEmgality vs NurtecEmgality vs Trokendi XrEmgality vs UbrelvyEmgality vs ZomigFioricet vs AxertFioricet vs FrovaFioricet vs RelpaxFioricet vs ZomigNurtec vs AimovigQulipta vs AimovigQulipta vs UbrelvyReyvow vs MaxaltReyvow vs UbrelvyReyvow vs ZecuityUbrelvy vs AimovigUbrelvy vs NurtecUbrelvy vs RelpaxUbrelvy vs RizatriptanUbrelvy vs Zolmitriptan
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.