Key takeaways
Isotretinoin (Claravis, Absorica) and adapalene (Differin) are both used to treat acne, but they have some key differences. Isotretinoin is an oral medication taken twice daily for severe nodular acne that hasn't responded to other treatments. It works by reducing oil production in the skin and speeding up skin renewal. Adapalene, on the other hand, is a topical treatment applied once daily for mild-to-moderate acne. It helps by unclogging pores and reducing inflammation. Isotretinoin requires strict precautions due to its risk of causing serious birth defects, and everyone taking it must enroll in the iPLEDGE program. Adapalene is available both by prescription and over-the-counter in lower strengths, and while it can cause skin irritation, it doesn't carry the same severe risks as isotretinoin. Additionally, isotretinoin can lead to more serious side effects like depression and liver damage, whereas adapalene's side effects are generally limited to skin irritation and increased sun sensitivity.
