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Enzyme Replacement Therapies

Enzyme replacement therapies are used to treat lysosomal storage disease, pancreatic insufficiency, and PKU. They work by increasing levels of certain enzymes in the body to delay symptoms.

Why are enzyme replacement therapies prescribed?

  1. Pancreatic Insufficiency (99%)
  2. Pancreatic Cancer (1%)
  3. Anemia (0%)
  4. Immunodeficiency (0%)
  5. Lysosomal Storage Disease (0%)
  6. PKU (0%)
  7. Sickle Cell Disease (0%)
  8. Nutritional Deficiency (0%)
  9. Metabolic Bone Disorders (0%)
  10. Chemotherapy Overdose (0%)

Key takeaways

Enzyme-replacement therapies are used to treat conditions like pancreatic insufficiency, mucopolysaccharidosis (MPS), and Gaucher disease. These therapies work by replacing the missing or deficient enzymes in your body, helping to break down substances that would otherwise build up and cause harm. Some of these medications are taken orally, while others are given as injections. Examples include pancrelipase (Creon, Pancreaze, Zenpep) for pancreatic insufficiency, Aldurazyme (laronidase) for certain forms of mucopolysaccharidosis type I (MPS I), and Cerezyme (imiglucerase) for Gaucher disease.

Prices for popular Enzyme Replacement Therapies medications
Viewing 25 of 35 medications
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Creon

as low as$1,246
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
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Pancreaze

as low as$140
Pancreaze (pancrelipase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes. Pancreaze is more popular than comparable drugs. There are currently no generic alternatives for Pancreaze.

GoodRx has partnered with InsideRx and Vivus to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Pancreaze is covered by some Medicare and insurance plans.
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Zenpep

as low as$218
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
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javygtor

as low as$171
SAPROPTERIN treats high phenylalanine levels in people with phenylketonuria (PKU). It works by helping your body break down phenylalanine. This prevents it from building up in the blood. Changes to diet are often combined with this medication.
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Pertzye

as low as$273
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
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Viokace

as low as$381
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
IDURSULFASE is used to replace an enzyme that is missing in patients with Hunter syndrome. It is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
URIDINE TRIACETATE treats orotic aciduria. It works by replacing an enzyme normally made by the body. This decreases symptoms.
Adzynma is part of the Enzyme Replacement Therapies class and treats Thrombocytopenia. Enzyme replacement therapies are used to treat lysosomal storage disease, pancreatic insufficiency, and PKU. They work by increasing levels of certain enzymes in the body to delay symptoms. Adzynma is only available as a brand name drug.
LARONIDASE treats mucopolysaccharidosis I (MPS I). It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.
CERLIPONASE ALFA treats late infantile neuronal ceroid lipofuscinosis type 2 (CLN2). It works by replacing an enzyme normally made by the body. This helps maintain the ability to crawl or walk.
ELIGLUSTAT treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
IMIGLUCERASE treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
Taliglucerase alfa is a man-made form of an enzyme that is missing in patients with Gaucher's disease. It is used to treat the symptoms of Gaucher's disease. It is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
PEGUNIGALSIDASE ALFA treats Fabry disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.
L-GLUTAMINE prevents the symptoms of sickle cell disease, such as pain crises and acute chest syndrome. It works by protecting your red blood cells from injury and improving blood flow.
AGALSIDASE BETA is used to replace an enzyme that is missing in patients with Fabry disease. It is not a cure.
MIGALASTAT treats Fabry Disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.
SEBELIPASE ALFA treats lysosomal acid lipase deficiency (LAL-D). It works by replacing an enzyme normally made by the body, which reduces the buildup of fatty substances (lipids) in the body. This decreases symptoms.
VELMANASE ALFA treats alpha-mannosidosis. It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.
ALGLUCOSIDASE ALFA treats Pompe disease. It works by replacing an enzyme normally made by the body, which reduces the buildup of sugar (glycogen) in your muscles. This decreases symptoms.
VESTRONIDASE ALFA is an enzyme replacement. It is used to treat the symptoms of Mucopolysaccharidosis type VII (MPS VII; Sly syndrome). This medicine is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
GALSULFASE is an enzyme replacement. It is used to treat the symptoms of mucopolysaccharidosis VI. This medicine is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
AVALGLUCOSIDASE ALFA is an enzyme replacement therapy. It treats late-onset Pompe disease. It is not a cure for late-onset Pompe disease.
Nityr (nitisinone) slows the breakdown of tyrosine. It is used to treat a rare disease called hereditary tyrosinemia type 1. Nityr is less popular than comparable drugs. There are currently no generic alternatives for Nityr. It may be covered by Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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