Key takeaways
Creon (pancrelipase) and Pancreaze (pancrelipase) are both enzyme replacement therapies used to treat exocrine pancreatic insufficiency (EPI) in children and adults. They work by providing the body with pancreatic enzymes that help digest fats, proteins, and carbohydrates. Both medications are taken orally with meals and snacks, and they share similar side effects, such as vomiting and stomach pain. However, there are some differences between them. Both are available in multiple strengths and can be mixed with a variety of soft, acidic foods. The dosing for infants also differs slightly, with Creon recommending 3000 units per 120 mL of formula or breastfeeding, compared to Pancreaze's 2600 units. Neither medication has a generic version available, and both carry risks of mouth irritation and high uric acid levels, especially if taken in high doses or for a long time.
