Key takeaways
Creon (pancrelipase) and Zenpep (pancrelipase) are both enzyme replacement therapies used to treat exocrine pancreatic insufficiency (EPI) in children and adults. They work by providing the digestive enzymes your body needs to break down fats, proteins, and carbohydrates. Both medications are taken orally with meals and snacks, and neither has a generic version available. However, they differ in some aspects. Common side effcts of both medications include stomach pain, cough, and headaches. Both medications can lead to high uric acid levels and scarring in the colon. They can be mixed with foods like applesauce and Greek yogurt. Both medications should be taken as prescribed, and you should inform your prescriber if you have any allergies to pork products, as these medications are made from pig pancreas tissue.
