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Aldurazyme Coupon - Aldurazyme 5ml of 2.9mg/5ml vial

Aldurazyme

laronidase
Used for Inherited Metabolic Diseases, Lysosomal Storage Disease
Used for Inherited Metabolic Diseases, Lysosomal Storage Disease

Aldurazyme (laronidase) is a medication used to treat symptoms of certain forms of a rare, genetic disease called mucopolysaccharidosis type I (MPS I). It's given by intravenous infusion (through the vein) once a week by a healthcare provider.

Last reviewed on April 25, 2022
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What is Aldurazyme (laronidase)?

What is Aldurazyme (laronidase) used for?

Certain forms of mucopolysaccharidosis type I (MPS I):

  • Hurler and Hurler-Scheie forms

  • Scheie form with moderate-to-severe symptoms

How Aldurazyme (laronidase) works

Aldurazyme (laronidase) works by replacing an enzyme that's missing in some forms of mucopolysaccharidosis type I (MPS I). People with MPS I don't have enough of or are missing an enzyme that's needed to break down long chains of sugar molecules, which can lead to cell, tissue, or organ damage.

Drug Facts

Common BrandsAldurazyme
Drug ClassEnzyme replacement therapy
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Aldurazyme (laronidase)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults and children 6 years or older:
  • Rash (36%)
  • Infusion reaction (32%)
  • Upper respiratory tract infection (e.g., common cold; 32%)
  • Flushing (23%)
  • Injection site reaction (18%)
  • Overactive reflexes (14%)
  • "Pins and needles" feeling (14%)
Children 6 months to 5 years old:
  • Infusion reaction (35%)
  • Ear infection (20%)

Other Side Effects

  • Injection site pain
  • Chest pain
  • Face swelling
  • Swelling in lower part of the body
  • Abscess (collection of pus)
  • Scarring or clouding of the eye
  • Low blood pressure
  • Low platelet count
  • High bilirubin levels

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reaction: slow heart rate, hives, breathing problems, swelling of the mouth or throat
  • Sudden heart and lung problems: fast breathing, trouble breathing, swelling, change in heart rate, chest tightness or pain, blue skin color

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

accumulation of pus

back pain

black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

chest pain

chest tightness

chills

clay-colored stools

confusion

dark urine

dizziness

drowsiness

facial swelling

faintness

fast, pounding, or irregular heartbeat or pulse

fever

flushing

headache

hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site

itching

lightheadedness when getting up from a lying or sitting position suddenly

loss of appetite

nausea or vomiting

pale skin

pinpoint red spots on skin

shortness of breath

skin rash

sweating

swollen, red, or tender area of infection

trouble breathing

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Less common

Cough

difficulty breathing

itching skin

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy breathing

redness of skin

tightness in chest

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, or discoloration of skin

blindness

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

decreased vision

diarrhea

difficulty in moving

ear congestion

feeling of pressure

loss of voice

muscle pain or stiffness

nasal congestion

overactive reflexes

pain in joints

runny nose

sneezing

sore throat

swelling of legs and feet

swelling or puffiness of face

varicose or spider veins

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Aldurazyme (laronidase)

thumbs-up

Pros

Only needs to be given once a week

Given and monitored by a healthcare provider

Can be given to both children and adults

Dose can be adjusted based on body weight

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Cons

Must be given by IV infusion (through the vein)

Commonly causes infusion reactions

Can worsen lung and heart problems

Unknown if it works or is safe for people with mild symptoms of the Scheie form of MPS I

pharmacist-tips

Pharmacist tips for Aldurazyme (laronidase)

pharmacist
  • Mark your appointments to get your Aldurazyme (laronidase) infusions on your calendar so you don't miss any doses.

    • Make sure there's someone who can drive you to and from your infusion appointments. Your provider might give you medications before or after your infusion that can make you sleepy to help manage certain reactions you might experience from the infusion.

      • You might experience an allergic reaction during or after your Aldurazyme (laronidase) infusion. If you have any signs or symptoms of an allergic reaction, including trouble breathing or rash, get medical help right away so you can be treated as soon as possible. Tell your provider about any reactions you have to Aldurazyme (laronidase).

        faqs

        Frequently asked questions about Aldurazyme (laronidase)

        Can Aldurazyme (laronidase) cure my MPS I condition?
        Aldurazyme (laronidase) can't cure MPS I, but it can help relieve your symptoms. It hasn't been studied in people with the Scheie form of MPS I who have mild symptoms, so this medication can only be used to treat people with this form who have moderate-to-severe symptoms. Also, Aldurazyme (laronidase) hasn't been studied for symptoms relating to brain and nervous system damage in people with MPS I. In clinical studies, people with Hurler, Hurler-Scheie, and Scheie forms of MPS I receiving Aldurazyme (laronidase) experienced improvement in lung and walking functions.
        How long does each treatment with Aldurazyme (laronidase) take?
        Aldurazyme (laronidase) infusions will typically start about 1 hour after pre-treatment, and can take about 3 to 4 hours. Pre-treatment refers to medications your provider might give you to lower your risk of getting an infusion reaction (e.g., fever, reddening of the skin, rash) or lower the severity of these reactions during your treatment. Pre-treatment can include allergy medications, medications to prevent fever, or both. Depending on your health conditions, you might be monitored by your provider for a few hours after the infusion for any serious reactions.
        Is Aldurazyme (laronidase) safe during pregnancy or breastfeeding?
        It's not known if Aldurazyme (laronidase) can harm your baby, so discuss with your provider before starting this medication if you're pregnant, planning to become pregnant, or breastfeeding. In pregnant animals, it didn't cause harm to unborn babies, but there isn't enough information in humans. If you have MPS I and are pregnant or breastfeeding, you can join the MPS I registry by visiting www.registrynxt.com or calling 1-800-745-4447, extension 15500. The registry can help monitor your health and your baby's health.
        Will I experience infusion reactions every time I go in for my treatment?
        Although infusion reactions are common, the chance of getting these reactions will lessen over time as you continue receiving Aldurazyme (laronidase) infusions. Most infusion reactions are mild to moderate in severity, and can commonly include redding of the skin, fever, headache, and rash.
        When should I stop getting Aldurazyme (laronidase) infusions?
        Speak to your provider about how long you should get Aldurazyme (laronidase) infusions. In clinical studies, people received this medication for about 6.5 months to 3.5 years. Depending on your health conditions, side effects, and how your MPS I improves, your provider might have you receive long-term treatment with Aldurazyme (laronidase).
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        What are the risks and warnings for Aldurazyme (laronidase)?

        Aldurazyme (laronidase) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

        risk-warning

        Severe allergic reactions

        Some people have experienced severe or life-threatening allergic reactions (e.g., anaphylaxis) during or up to 3 hours after Aldurazyme (laronidase) infusions. These reactions can include low blood pressure; slowed heart rate; hives; trouble breathing; high-pitched, wheeze-like sound when breathing; fast breathing; or tightening of the airways. People with breathing or lung problems can have a higher risk of worsened breathing issues while getting Aldurazyme (laronidase).

        Your provider will monitor you during your infusion in case a severe reaction occurs. Let your provider know if you experience any signs of an allergic reaction so they can give you the appropriate treatment right away. If you have lung problems or have had reactions in the past, your provider might monitor you for a longer period of time.

        risk-warning

        Worsening of breathing problems in certain people

        • Risk factors: Sudden fever | Breathing or lung problems

          People who currently have a fever that occurred suddenly without cause or people with breathing or lung problems (e.g., respiratory illness) might have a higher risk of getting an infusion reaction, especially breathing problems, from Aldurazyme (laronidase). Let your provider know if you have sleep apnea or if you use oxygen or continuous positive airway pressure (CPAP) during sleep so they can make it available for you to use if you need it during or after your treatment. Let your provider know your full medical history before starting treatment with Aldurazyme (laronidase), since you might need to be monitored more carefully.

          risk-warning

          Worsening of lung or heart problems in certain people

          • Risk factors: Fluid overload | Lung or heart problems

            People who build up fluid easily (or have lung or heart problems and need to limit their fluids) might experience sudden worsening of their condition during Aldurazyme (laronidase) infusions. Let your provider know your full medical history before starting treatment with Aldurazyme (laronidase), since you might need to be monitored for a longer period of time.

            risk-warning

            Infusion reactions

            Aldurazyme (laronidase) can cause reactions during the infusion. These reactions include flushing (feeling warm all of a sudden), fever, chills, headache, and rash. Because of this, your provider might give you medications to lower your risk of getting a fever or other reaction before your infusion. Let your provider know right away if you experience any reactions during treatment, and they can slow down how fast you get Aldurazyme (laronidase) through your vein (the infusion rate), stop your infusion temporarily, or give you medications to relieve your symptoms.

            dosage

            Aldurazyme (laronidase) dosage forms

            Typical dosing for Aldurazyme (laronidase)

            Aldurazyme (laronidase) is only available as an intravenous (IV) infusion that's administered by a healthcare provider. The recommended dose is 0.58 mg/kg of body weight, given as an infusion into the vein once a week. Your provider will determine the appropriate dose based on your body weight and health conditions.

            interactions

            Interactions between Aldurazyme (laronidase) and other drugs

            Aldurazyme (laronidase) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Aldurazyme (laronidase). Please note that only the generic name of each medication is listed below.

            Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

            images

            Aldurazyme (laronidase) images

            yellow - ALDURAZYME 2.9mg / 5mL Solution for Injection
            This medicine is Yellow Vial.yellow - ALDURAZYME 2.9mg / 5mL Solution for Injection

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