Enzyme-replacement therapies are used to treat conditions like pancreatic insufficiency, mucopolysaccharidosis (MPS), and Gaucher disease. These therapies work by replacing the missing or deficient enzymes in your body, helping to break down substances that would otherwise build up and cause harm. Some of these medications are taken orally, while others are given as injections. Examples include pancrelipase (Creon, Pancreaze, Zenpep) for pancreatic insufficiency, Aldurazyme (laronidase) for certain forms of mucopolysaccharidosis type I (MPS I), and Cerezyme (imiglucerase) for Gaucher disease.