Skip to main content

Enzyme Replacement Therapies

Enzyme replacement therapies are used to treat lysosomal storage disease, pancreatic insufficiency, and PKU. They work by increasing levels of certain enzymes in the body to delay symptoms.

Why are enzyme replacement therapies prescribed?

  1. Pancreatic Insufficiency (100%)
  2. Anemia (0%)
  3. Pancreatic Cancer (0%)
  4. Immunodeficiency (0%)
  5. Lysosomal Storage Disease (0%)
  6. PKU (0%)
  7. Sickle Cell Disease (0%)
  8. Nutritional Deficiency (0%)
  9. Metabolic Bone Disorders (0%)
  10. Chemotherapy Overdose (0%)

Key takeaways

Enzyme-replacement therapies are used to treat conditions like pancreatic insufficiency, mucopolysaccharidosis (MPS), and Gaucher disease. These therapies work by replacing the missing or deficient enzymes in your body, helping to break down substances that would otherwise build up and cause harm. Some of these medications are taken orally, while others are given as injections. Examples include pancrelipase (Creon, Pancreaze, Zenpep) for pancreatic insufficiency, Aldurazyme (laronidase) for certain forms of mucopolysaccharidosis type I (MPS I), and Cerezyme (imiglucerase) for Gaucher disease.

Prices for popular Enzyme Replacement Therapies medications
Viewing 25 of 36 medications
capsule icon

Creon

as low as$1,256
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
capsule icon

Pancreaze

as low as$133
Pancreaze (pancrelipase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes. Pancreaze is more popular than comparable drugs. There are currently no generic alternatives for Pancreaze.

GoodRx has partnered with InsideRx and Vivus to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Pancreaze is covered by some Medicare and insurance plans.
capsule icon

Zenpep

as low as$210
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
kit icon

Adzynma

as low as$7
Adzynma is part of the Enzyme Replacement Therapies class and treats Thrombocytopenia. Enzyme replacement therapies are used to treat lysosomal storage disease, pancreatic insufficiency, and PKU. They work by increasing levels of certain enzymes in the body to delay symptoms. Adzynma is only available as a brand name drug.
tablet icon

Viokace

as low as$21
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
carton icon

javygtor

as low as$166
SAPROPTERIN treats high phenylalanine levels in people with phenylketonuria (PKU). It works by helping your body break down phenylalanine. This prevents it from building up in the blood. Changes to diet are often combined with this medication.
LARONIDASE treats mucopolysaccharidosis I (MPS I). It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.
AGALSIDASE BETA is used to replace an enzyme that is missing in patients with Fabry disease. It is not a cure.
L-GLUTAMINE prevents the symptoms of sickle cell disease, such as pain crises and acute chest syndrome. It works by protecting your red blood cells from injury and improving blood flow.
capsule icon

Pertzye

as low as$1,307
PANCRELIPASE treats a condition where the pancreas does not make enough of the enzymes needed to digest food. It works by replacing those enzymes, so your body can break down food. This improves nutrition and decreases fatty bowel movements.
IMIGLUCERASE treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
CIPAGLUCOSIDASE ALFA treats Pompe disease. It works by replacing an enzyme normally made by the body, which reduces the buildup of sugar (glycogen) in your muscles. This decreases symptoms.
PEGUNIGALSIDASE ALFA treats Fabry disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.
OLIPUDASE ALFA treats acid sphingomyelinase deficiency (ASMD). It works by replacing an enzyme normally made by the body, which reduces the buildup of a certain lipid (sphingomyelin) in your liver, spleen, and lungs. This decreases some symptoms of ASMD.
CERLIPONASE ALFA treats late infantile neuronal ceroid lipofuscinosis type 2 (CLN2). It works by replacing an enzyme normally made by the body. This helps maintain the ability to crawl or walk.
IDURSULFASE is used to replace an enzyme that is missing in patients with Hunter syndrome. It is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
URIDINE TRIACETATE treats orotic aciduria. It works by replacing an enzyme normally made by the body. This decreases symptoms.
AVALGLUCOSIDASE ALFA is an enzyme replacement therapy. It treats late-onset Pompe disease. It is not a cure for late-onset Pompe disease.
ELIGLUSTAT treats Gaucher disease. It works by decreasing the amount of fatty substances (lipids) your body makes, which prevents the buildup of lipids in the spleen, liver, and other tissues. This decreases symptoms.
Taliglucerase alfa is a man-made form of an enzyme that is missing in patients with Gaucher's disease. It is used to treat the symptoms of Gaucher's disease. It is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
MIGALASTAT treats Fabry Disease. It works by replacing an enzyme normally made by the body, which reduces the buildup fatty substances (lipids) in the eyes, kidneys, heart, and other tissues. This decreases symptoms and the risk of serious health problems.
SEBELIPASE ALFA treats lysosomal acid lipase deficiency (LAL-D). It works by replacing an enzyme normally made by the body, which reduces the buildup of fatty substances (lipids) in the body. This decreases symptoms.
SAPROPTERIN treats high phenylalanine levels in people with phenylketonuria (PKU). It works by helping your body break down phenylalanine. This prevents it from building up in the blood. Changes to diet are often combined with this medication.
VELMANASE ALFA treats alpha-mannosidosis. It works by replacing an enzyme normally made by the body, which reduces the buildup of complex sugars in the body. This decreases symptoms.
ALGLUCOSIDASE ALFA treats Pompe disease. It works by replacing an enzyme normally made by the body, which reduces the buildup of sugar (glycogen) in your muscles. This decreases symptoms.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

Subscribe and save

Get prescription saving tips and more from GoodRx Health. Enter your email to sign up

By signing up, I agree to GoodRx’s Terms of Use and Privacy Policy, and to receive marketing messages from GoodRx.

Latest Articles

Browse medications

View All
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.