Altreno (tretinoin) is a retinoid medication that's used to treat acne in people 9 years and older. Altreno (tretinoin) is a lotion that you apply once daily to the affected area(s) on your skin. It isn't sold over the counter and requires a prescription. Some side effects of Altreno (tretinoin) include dryness, pain, and redness where you apply the medication.
Acne
Tretinoin is a retinoid, which is a chemical formed from vitamin A. It's thought to help treat acne by unclogging pores in your skin that are plugged with dead skin cells and excessive oil. It also replaces your old skin cells with new skin cells to prevent acne and pimples from forming.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Applied once daily
Applied directly on the affected area(s)
Can use for acne in children as young as 9 years old
Can take many weeks before you notice improvement in your skin
Causes your skin to be more sensitive to sunlight, which can lead to sunburns
Might not be the best option for people with fish allergies
Apply Altreno (tretinoin) onto the affected skin once daily. For best results, use it consistently (around the same time each day) and exactly as prescribed.
When you're ready to use Altreno (tretinoin), first gently wash your skin and pat it dry. Then, squeeze or pump some lotion onto your fingertip and apply the medication as a thin layer over the affected area(s) on your skin.
Only apply Altreno (tretinoin) to your skin. Don't get it in your eyes, mouth, corners of your nose, or vagina. Wash your hands after you use the medication to avoid getting it on other parts of your body. Otherwise, it could cause irritation.
Don't apply Altreno (tretinoin) to areas of broken skin, since this could cause more medication to get absorbed into your body and raise your risk of side effects. Also avoid applying the medication to skin that has eczema or to sunburned skin; doing so can cause more irritation.
It's normal for Altreno (tretinoin) to cause skin dryness, redness, pain, and peeling. You can use a moisturizer to try to help soothe dry skin. Contact your prescriber if these side effects are very bothersome or don't go away.
Altreno (tretinoin) can make your skin more sensitive to sunlight. Avoid sunlamps, tanning beds, and ultraviolet light during treatment with this medication. If you need to go outside, make sure to wear sunscreen and protective clothing to protect your skin from sunburns.
You can use Altreno (tretinoin) with makeup. Just make sure to apply the medication first and wait a few minutes before putting on your makeup on top.
Altreno (tretinoin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Sensitive skin | Eczema
Altreno (tretinoin) can cause skin redness, dryness, pain, and irritation where you apply it. Consider using a moisturizer to help with dry skin. Stop using the medication until your skin heals if your skin irritation doesn't go away. Avoid areas of skin that are sunburned or have eczema, since these areas are more prone to irritation. Discuss with your primary care provider or dermatologist to see whether you need to use Altreno (tretinoin) less often so that you can tolerate it better or whether you need a different medication.
Risk factors: High levels of sun exposure | Having skin that burns easily | Living in a hot climate | Working outdoors
Using Altreno (tretinoin) can make your skin more sensitive to both natural sunlight and artificial sunlight from sunlamps. This can cause your skin to burn more easily. Having skin that's more sensitive to light might also raise your risk of early aging of the skin or skin cancer.
It's important to protect your skin from sunlight by finding shade outdoors, using sunscreen when you're outside (even on cloudy days), and wearing sun-protective clothing (like hats). Also avoid using sunlamps. Ask your primary care provider or dermatologist about which SPF (sun protection factor) level of sunscreen will protect you best. Stop using Altreno (tretinoin) until your skin fully heals if you get sunburned.
Risk factors: Allergy to fish or fish-containing products
Altreno (tretinoin) is made with fish proteins. Be careful using this medication if you have an allergy to fish. Let your prescriber know if you develop a red, itchy rash (hives). You might have to stop using Altreno (tretinoin).
Apply a thin layer to the affected area(s) once daily.
Treatment of papules and pustules in adults with mild-to-moderate rosacea
By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
Bausch Health US, LLC. (2020). Altreno- tretinoin lotion [package insert]. DailyMed.
Bhatia, N., et al. (2020). A split-face, controlled study to assess the compatibility of tretinoin 0.05% acne lotion with facial foundation makeup. The Journal of Clinical and Aesthetic Dermatology.
Kircik, L. H., et al. (2019). Matrix revisited: Innovative approach for tretinoin. Journal of Drugs in Dermatology.
Mother To Baby | Fact Sheets. (2022). Tropical tretinoin. Organization of Teratology Information Specialists (OTIS).
VanBuren, C. A., et al. (2022). Vitamin A in skin and hair: An update. Nutrients.
Yoham, A. L., et al. (2023). Tretinoin. StatPearls.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.