lisdexamfetamine
Vyvanse, the brand name for lisdexamfetamine, is a stimulant medication. It's used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It can also treat binge eating disorder (BED) in adults. Vyvanse (lisdexamfetamine) comes as capsules and chewable tablets. It's taken once per day in the morning. The dosage starts low and gets adjusted based on how you respond to the medication. Common side effects include trouble sleeping and loss of appetite. Vyvanse (lisdexamfetamine) is a controlled substance because it has a high risk of misuse and dependency.
What is Vyvanse (lisdexamfetamine)?
What is Vyvanse (lisdexamfetamine) used for?
Attention deficit-hyperactivity disorder (ADHD) in people 6 years and older
Moderate-to-severe binge eating disorder (BED) in adults
How Vyvanse (lisdexamfetamine) works
Vyvanse (lisdexamfetamine) is a stimulant medication. It's not exactly known how the medication works to treat ADHD and binge eating disorder. But researchers think it works by raising the levels of chemicals in your brain called norepinephrine, dopamine, and serotonin. These chemicals are thought to help control how well you focus and how you eat.
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What are the risks and warnings for Vyvanse (lisdexamfetamine)?
Vyvanse (lisdexamfetamine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of misuse and addiction
Risk factors: History of substance or alcohol use disorder | Taking more Vyvanse (lisdexamfetamine) than prescribed
Vyvanse (lisdexamfetamine) has a high potential to be misused, which can be dangerous. Misusing this medication can cause serious side effects, like fast heart rate, high blood pressure, aggressive behavior, and even thoughts of hurting yourself or others. It can also lead to addiction or a deadly overdose.
To stay safe, take Vyvanse (lisdexamfetamine) exactly as prescribed to you. Don't change the dose or how often you take it without asking your prescriber first. Talk to your prescriber if you're worried about this risk.
Risks to people with serious heart problems
There have been reports of sudden death in people with heart problems taking stimulants like Vyvanse (lisdexamfetamine). Before starting this medication, tell your prescriber if you have any heart problems. This can include coronary artery disease (CAD). Other issues to note are problems with the structure of your heart or your heart rhythm (arrhythmia). Your prescriber can make sure it's safe for you to take Vyvanse (lisdexamfetamine).
Higher blood pressure and faster heart rate
Stimulants including Vyvanse (lisdexamfetamine) can make your blood pressure and heart rate go up. On average, blood pressure can rise by 2 mmHg to 4 mmHg. And, heart rate can go up by 3 to 6 beats per minute.
Let your prescriber know if you have high blood pressure or a history of a fast heart rate. They can check that Vyvanse (lisdexamfetamine) is safe for you. Tell your care team if your blood pressure is higher than usual or if you feel your heart racing.
Strange thoughts or behavior
Risk factors: History of psychotic episodes or other manic psychiatric conditions | Personal or family history of depression | Family history of suicide or bipolar disorder
Stimulants like Vyvanse (lisdexamfetamine) can sometimes change how you think or act. This can include being aggressive, acting recklessly, or having too much energy. Some people might have hallucinations (seeing or hearing things that aren't there) or delusions (believing things that aren't true).
Sometimes, this can happen to people who've never had these problems before. But it's more likely to be worse if you already have a mental health problem like psychosis or bipolar disorder. Your prescriber will check your risk before you start Vyvanse (lisdexamfetamine).
If you start to act unusual or have strange thoughts while taking Vyvanse (lisdexamfetamine), let your prescriber know. You might have to stop the medication.
Slow growth in children
Stimulants like Vyvanse (lisdexamfetamine) have been linked to weight loss and slow growth (both in height and weight) in children. Your child's primary care provider will check their height and weight often. If your child isn't growing as expected, the primary care provider might suggest taking a break from the medication.
Talk to your child's prescriber or primary care provider if you notice your child has lost a lot of weight. Also, talk to them if you're worried about how much your child is growing.
Problems with blood flow in the arms and legs, including Raynaud's phenomenon
Stimulants like Vyvanse (lisdexamfetamine) have been linked to problems with blood flow in the arms and legs. This can include Raynaud's phenomenon, which is a problem with blood flow to your fingers and toes.
Raynaud's phenomenon can lead to color changes in your fingers and toes. They can turn pale, blue, or red depending on how much blood gets to them. Your fingers and toes might also feel cold, numb, or painful. If this happens, it's usually mild and happens occasionally. But rarely, it can lead to other problems like sores or tissue damage.
Let your care team know if you have any of these symptoms while taking Vyvanse (lisdexamfetamine). Usually, they get better after your prescriber lowers your dose or after you stop the medication.
Serotonin syndrome
Risk factors: Taking monoamine oxidase inhibitors (MAOI) within 14 days of Vyvanse (lisdexamfetamine) | Taking other medications that raise serotonin levels in your brain
Taking Vyvanse (lisdexamfetamine) with some other medications can raise the risk of serotonin syndrome. This is a rare, but serious problem that happens when there's too much serotonin in the brain.
Medications that can make serotonin syndrome more likely are those that raise serotonin levels in the brain. These include antidepressants, MAOIs, and migraine medications called triptans. Tell your prescriber and pharmacist about all the medications you take or plan to take. They can help keep you safe and make changes if needed.
Get medical help right away if you notice signs of serotonin syndrome. These include a fast heart rate, sweating a lot, muscle stiffness, high fever, changes in behavior, and confusion.
What are the side effects of Vyvanse (lisdexamfetamine)?
Common Side Effects
- Lower appetite (27%)
- Trouble sleeping (27%)
- Dry mouth (26%)
- Dry mouth (36%)
- Trouble sleeping (20%)
Other Side Effects
- Nausea
- Diarrhea
- Constipation
- Stomach pain
- Lower appetite
- Weight loss
- Anxiety
- Feeling jittery
- Faster heart rate
- Sweating a lot
Serious Side Effects
- Changes in thought or behavior: manic episodes, hallucinations, delusional thinking
- Serotonin syndrome: fast heart rate, fever, sweating, muscle stiffness or spasms, confusion
- Allergic reaction: rash; hives; trouble breathing; swelling of face, lips, tongue, or throat
Source: DailyMed
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The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Increase in blood pressure
- Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- Prolonged or painful erection
- Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
- Seizures
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Dry mouth
- Headache
- Loss of appetite with weight loss
- Nausea
- Stomach pain
- Trouble sleeping
Pros and cons of Vyvanse (lisdexamfetamine)
Pros
Can help with ADHD for up to 14 hours with each dose
For binge eating disorder, can lower the number of binge-eating days per week by about one and a half days
Has a few options for people who have trouble swallowing pills whole (open the capsule or switch to chewable tablets)
Cons
Has a risk of misuse and dependency
A controlled medication, so there are special requirements for getting the prescription filled
Might need to take gradually lower doses before stopping to avoid withdrawal symptoms
Not the best choice for people with heart conditions
Pharmacist tips for Vyvanse (lisdexamfetamine)
Take Vyvanse (lisdexamfetamine) as soon as you wake up every day. This medication might make you have trouble sleeping if you take it later in the day.
You can take Vyvanse (lisdexamfetamine) with or without food. Make sure to limit acidic foods that you eat or drink. This includes fruit juice, citrus fruits, and foods high in vitamin C. These foods and drinks might lower the amount of medication that gets absorbed into your body. This might affect how well it works for you.
For the Vyvanse (lisdexamfetamine) capsules: Swallow the capsules whole. Don't crush or chew them. But if needed, you can open the capsule, empty everything inside into a cup, and mix with yogurt, water, or orange juice. Once mixed well, consume all of it right away.
For the Vyvanse (lisdexamfetamine) chewable tablets: Be sure to chew the tablets well before swallowing. Don't swallow the chewable tablets whole; they might not get absorbed well enough in your body to work.
It's usually a good idea to drink coffee or other caffeinated beverages in moderation when you're taking Vyvanse (lisdexamfetamine). Like the medication, caffeine can also be a stimulant. Taking the medication with caffeinated things can raise your risk of side effects. These can include high blood pressure, trouble sleeping, and low appetite. If you feel tired, talk to your care team about other ways to stay awake and alert.
Avoid driving the first few days after you start Vyvanse (lisdexamfetamine) and after your dose changes. Wait until you know how this medication makes you feel. It might make it dangerous for you to drive.
You might feel less hungry while taking Vyvanse (lisdexamfetamine). Be sure you're eating balanced meals when you do. Speak with your prescriber if you're worried about your nutrition.
Talk to your prescriber if you have tics or Tourette syndrome. Vyvanse (lisdexamfetamine) can worsen these problems. Your prescriber can help you decide if the medication is a good choice.
Tell your prescriber and pharmacist about all the medications and supplements you take or plan to take. They can check to make sure they're all safe to take together. Vyvanse (lisdexamfetamine) can interact with many medications, which can be harmful. For example, it can interact with antidepressants, blood pressure medications, and decongestants.
Take Vyvanse (lisdexamfetamine) exactly like your prescriber told you to. Don't suddenly lower your dose or stop taking it without talking to them first. If you do, you might have uncomfortable withdrawal symptoms. These include uneasiness, trouble thinking clearly, and trouble sleeping. If you want to stop this medication, your prescriber will slowly lower your dose before you can completely stop.
Taking too much Vyvanse (lisdexamfetamine) by accident can be very dangerous. An overdose can look like restlessness, fast breathing, irregular heartbeat, irritability, and paranoia. Be sure you and your loved ones know what an overdose can look like. Call 911 right away if this happens.
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Vyvanse (lisdexamfetamine) dosage forms
Typical dosing for Vyvanse (lisdexamfetamine)
ADHD
Adults and children 6 years and older: The typical starting dose is 30 mg by mouth once per day in the morning. Your prescriber might adjust your dose depending on your needs. The recommended dose is 30 mg to 70 mg once per day.
Binge eating disorder
Adults only: The typical starting dose is 30 mg by mouth once per day. Your prescriber might adjust your dose depending on how the medication is working for you. The recommended dose is 50 mg to 70 mg once per day.
Your dose might differ if you have severe kidney problems.
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How much does Vyvanse (lisdexamfetamine) cost?
Vyvanse (lisdexamfetamine) contraindications
Allergy to amphetamine products
Currently take or have taken a monoamine oxidase inhibitor (MAOI), linezolid (Zyvox), or methylene blue (ProvayBlue) in the last 14 days
What are alternatives to Vyvanse (lisdexamfetamine)?
Attention deficit-hyperactivity disorder (ADHD) in people 6 years and older
Moderate-to-severe binge eating disorder (BED) in adults
Attention-deficit hyperactivity disorder (ADHD)
Attention-deficit hyperactivity disorder (ADHD) in people 6 years and older
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References
Best studies we foundAmerican Academy of Child and Adolescent Psychiatry. (2017). ADHD & the brain.
Centers for Disease Control and Prevention. (2025). Diagnosing tic disorders.
Coghill, D. R., et al. (2014). A systematic review of the safety of lisdexamfetamine dimesylate. CNS Drugs.
Ermer, J. C., et al. (2016). Lisdexamfetamine dimesylate: Prodrug delivery, amphetamine exposure and duration of efficacy. Clinical Drug Investigation.
Fornaro, M., et al. (2016). Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: Systematic review and exploratory meta-analysis of publicly available placebo-controlled, randomized clinical trials. Neuropsychiatric Disease and Treatment.
Gamcsik, S. (2024). Stimulant versus non-stimulant treatment options for ADHD. American Association of Psychiatric Pharmacists.
Inchiosa, M. A., Jr. (2011). Experience (mostly negative) with the use of sympathomimetic agents for weight loss. Journal of Obesity.
Jeffers, A., et al. (2013). Misuse of prescription stimulants for weight loss, psychosocial variables, and eating disordered behaviors. Appetite.
Madaan, V., et al. (2013). Update on optimal use of lisdexamfetamine in the treatment of ADHD. Neuropsychiatric Disease and Treatment.
Martin, D., et al. (2023). Amphetamine. StatPearls.
MedlinePlus. (2023). Neonatal abstinence syndrome.
MedlinePlus. (2025). Drug use and addiction.
Moore, C. F., et al. (2018). Neuropharmacology of compulsive eating. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.
Moran, L. V., et al. (2019). Pyschosis with methylphenidate or amphetamine in patients with ADHD. The New England Journal of Medicine.
National Institute of Neurological Disorders and Stroke. (2025). Tourette syndrome.
National Institute on Drug Abuse. (2011). Misuse of prescription drugs research report: Overview.
Takeda Pharmaceuticals America, Inc. (2023). Vyvanse- lisdexamfetamine dimesylate capsule.; Vyvanse- lisdexamfetamine dimesylate tablet, chewable [package insert]. DailyMed.
U.S. Department of Justice/Drug Enforcement Administration. (2024). Amphetamines.
U.S. Food and Drug Administration. (2024). Some medicines and driving don’t mix.
Wolraich, M. L., et al. (2019). Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics.
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