The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Trouble concentrating
- Lightheadedness
- Dizziness
- Headache
- Dry mouth
- Nausea
- Vomiting
- Constipation
- Trouble breathing
- Sweating
Less Common Side Effects
- Tired feeling
- Falling
- Swelling of the arms or legs
- High or low blood pressure
- Blurry vision
- Confusion
- Sensitivity to light
- Hallucinations
- Heartburn
- Diarrhea
- Stomach pain
Promethazine/Codeine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
- Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, slow heartbeat, upper right-sided stomach pain, dark urine, cold or clammy skin, yellowing of your skin or eyes
- Opioid withdrawal: anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
- Neuroleptic malignant syndrome (NMS): fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
Source: DailyMed
The following Promethazine/Codeine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Bluish lips or skin
chills
clay-colored stools
cold sweats
confusion
dark urine
decrease in the frequency of urination
decrease in the urine volume
difficult or troubled breathing
difficulty in passing urine (dribbling)
dizziness
dizziness, faintness, or lightheadedness when getting up from lying or sitting position
fast, pounding, or irregular heartbeat or pulse
feeling of warmth
headache
high fever
hives or welts, itching, or rash
increased sweating
irregular, fast or slow, or shallow breathing
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
loss of bladder control
noisy breathing
not breathing
pale or blue lips, fingernails, or skin
rectal bleeding
redness of the face, neck, arms, and occasionally, upper chest
redness of the skin
seeing, hearing, or feeling things that are not there
seizures
severe muscle stiffness
shakiness in the legs, arms, or hands
stomach pain
sweating
tightness in the chest
tiredness
trembling or shaking of the hands or feet
unpleasant breath odor
unusual tiredness or weakness
unusually pale skin
vomiting of blood
yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Bad dreams
blurred or loss of vision
confusion as to time, place, or person
continuing ringing or buzzing or other unexplained noise in the ears
difficulty having a bowel movement
disturbed color perception
double vision
drowsiness
false or unusual sense of well-being
halos around lights
hearing loss
holding false beliefs that cannot be changed by fact
increased sensitivity of the skin to sunlight
night blindness
overbright appearance of lights
redness or other discoloration of the skin
relaxed and calm feeling
severe sunburn
sleepiness
trouble sleeping
tunnel vision
unusual excitement, nervousness, or restlessness
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
