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Opdualag Coupon - Opdualag 20ml of 240mg/80mg vial

Opdualag

nivolumab / relatlimab
Used for Melanoma
Used for Melanoma

Opdualag is a pre-mixed combination of two medications: nivolumab and relatlimab (or relatlimab-rmbw). Both are immunotherapy medications that work to treat advanced and metastatic melanoma skin cancer by activating your immune system to fight cancer cells. Opdualag (nivolumab / relatlimab) is given through the vein (IV, intravenously) at a doctor’s office or infusion center, typically once every 4 weeks. Possible side effects of this medication include rash, diarrhea, and muscle pain.

Last reviewed on August 3, 2023
basics-icon

What is Opdualag (nivolumab / relatlimab)?

What is Opdualag (nivolumab / relatlimab) used for?

  • Melanoma skin cancer that has spread or can’t be removed by surgery (people ages 12 years and older)

How Opdualag (nivolumab / relatlimab) works

Our immune system plays an important role in our body, for example, to fight infections. The immune system can also attack and kill cancer cells it recognizes as abnormal. Some cancer cells can hide from the immune system by using the programmed-death-1 (PD-1) or the lymphocyte activation gene-3 (LAG3) pathway. When a cancer cell uses one or both of these pathways, it stops our immune cells from attacking the cancer cell. This allows cancer to grow.

Opdualag (nivolumab / relatlimab) is a combination medication that blocks both the PD-1 (nivolumab) and LAG3 (relatlimab) pathways. When these pathways are blocked, the immune system is activated to attack cancer cells. As a result, the immune system can kill cancer cells and stop cancer cells from growing.

Are you looking for information on Opdivo (Nivolumab) instead?

Drug Facts

Common BrandsOpdualag
Drug ClassPD-1 and LAG-3 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Opdualag (nivolumab / relatlimab) essentials

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What are the side effects of Opdualag (nivolumab / relatlimab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Headache
  • Nausea
  • Lower appetite
  • Cough

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious immune-related side effects: rash, diarrhea, trouble breathing, severe stomach pain, chest pain
  • Serious reaction during infusion: itching, trouble breathing, fast heart beat, feeling warm or hot

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dry cough, shortness of breath or trouble breathing
  • Eye pain, redness, irritation, or discharge with blurry or decreased vision
  • Heart muscle inflammation—unusual weakness or fatigue, shortness of breath, chest pain, fast or irregular heartbeat, dizziness, swelling of the ankles, feet, or hands
  • Hormone gland problems—headache, sensitivity to light, unusual weakness or fatigue, dizziness, fast or irregular heartbeat, increased sensitivity to cold or heat, excessive sweating, constipation, hair loss, increased thirst or amount of urine, tremors or shaking, irritability
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
  • Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Opdualag (nivolumab / relatlimab)

thumbs-up

Pros

Recommended treatment for people with advanced melanoma skin cancer

Includes two medications in a single infusion, so more convenient

Doesn’t typically cause side effects like hair loss or vomiting that are commonly seen with traditional chemotherapy

thumbs-down

Cons

Given as an infusion through an IV, which requires using a needle

Might cause certain immune-related side effects such as rash and diarrhea

Might require treatment with corticosteroids to manage side effects

pharmacist-tips

Pharmacist tips for Opdualag (nivolumab / relatlimab)

pharmacist
  • Contact your provider right away if you have immune-related side effects such as a new skin rash, diarrhea, or trouble breathing. These can be signs that your immune system has become too active as a result of Opdualag (nivolumab / relatlimab) treatment.

    • If you have immune-related side effects such as new skin rash or diarrhea, don’t take over-the-counter medications to treat it without contacting your provider first. Over-the-counter medications you might use, like loperamide (Imodium-AD) for diarrhea, for example, won’t work as well. Usually, these side effects need to be quickly treated with a corticosteroid, such as prednisone.

      • Some immune-related side effects, like liver and kidney changes, usually won’t cause symptoms. Instead, these side effects can be detected in the results of your lab tests. It’s important that you keep up with recommended lab work so your provider can follow the results and monitor you for these side effects.

        • The typical treatment for immune-related side effects is a corticosteroid such as prednisone. If your prescriber gives you a corticosteroid to take, don’t stop taking it suddenly because doing so can cause uncomfortable side effects, such as weakness and nausea. When it’s time to stop the steroid medication, your provider will give you a plan to do so slowly and safely (tapering) to avoid these symptoms.

          • Opdualag (nivolumab / relatlimab) can cause harm to an unborn baby. If you’re a female who can have children, make sure to use effective birth control while receiving Opdualag (nivolumab / relatlimab) and for 5 months after the last dose. Let your provider know if you become pregnant during or after treatment.

            • Females who are taking Opdualag (nivolumab / relatlimab) shouldn’t breastfeed. Opdualag (nivolumab / relatlimab) hasn’t been studied in human milk, but because of the possible risks to a baby, it’s best to avoid nursing if you’re taking Opdualag (nivolumab / relatlimab) and for 5 months after the last dose.

              faqs

              Frequently asked questions about Opdualag (nivolumab / relatlimab)

              Is Opdualag (nivolumab / relatlimab) a chemotherapy medication?
              Opdualag (nivolumab / relatlimab) isn’t considered traditional chemotherapy. Chemotherapy medications typically work by directly attacking rapidly growing cancer cells. Instead, Opdualag (nivolumab / relatlimab) is an immunotherapy medication that works by activating your immune system to attack the cancer cells. Ask your provider if you’re unsure about which type of cancer treatment is best for you.
              Why does Opdualag (nivolumab / relatlimab) have two names?
              A single dose of Opdualag (nivolumab / relatlimab) includes two medications, nivolumab and relatlimab, combined together in the same treatment. Both nivolumab and relatlimab are immunotherapy medications that activate your immune system, but they do this in different ways. By activating your immune system through two different pathways, Opdualag (nivolumab / relatlimab) works to kill cancer cells and stop them from growing. Sometimes, two medications need to be given separately, but Opdualag (nivolumab / relatlimab) can be given together as one single infusion.
              What are the immune-related side effects of Opdualag (nivolumab / relatlimab)?
              Opdualag (nivolumab / relatlimab) doesn’t cause the same side effects typically seen with chemotherapy. Because Opdualag (nivolumab / relatlimab) works by activating your immune system, side effects are usually called immune-related adverse events, or irAEs. These happen when the immune system becomes too active during treatment and attacks healthy cells in addition to cancer cells. The most common reactions happen in the skin (i.e., rash), in the gut (i.e., diarrhea), and lungs (i.e., trouble breathing). If you experience any of these side effects during treatment with Opdualag (nivolumab / relatlimab) let your provider know right away so they can help you manage them.
              Can I continue taking Opdualag (nivolumab / relatlimab) if I have immune-related side effects?
              It depends on what type of immune-related side effect you have. Sometimes, you can keep taking Opdualag (nivolumab / relatlimab) while your provider treats the side effect, for example if you have thyroid changes. But it’s more common that you’ll need to take a break from Opdualag (nivolumab / relatlimab) while your provider manages your side effects. Your provider will most likely prescribe a corticosteroid, like prednisone, to calm your immune system down. If your symptoms gets better, your provider might ask you to restart Opdualag (nivolumab / relatlimab) again. But if your side effects are severe, your provider might ask you to permanently stop taking Opdualag (nivolumab / relatlimab).
              Does Opdualag (nivolumab / relatlimab) cause nausea and vomiting?
              Opdualag (nivolumab / relatlimab) does not typically cause nausea. If nausea does occur, it’s usually mild. Vomiting has not been commonly reported by people taking Opdualag (nivolumab / relatlimab) in clinical studies. If you do have nausea while taking Opdualag (nivolumab / relatlimab), talk to your provider. There are several lifestyle changes they might recommend, such as eating smaller meals and avoiding certain foods. Your provider might also recommend a medication to help manage it, such as ondansetron (Zofran) or prochlorperazine (Compazine).
              How long should I take Opdualag (nivolumab / relatlimab)?
              How long you take Opdualag (nivolumab / relatlimab) depends on several factors, such as how well the medication is working for you and if you’re having any side effects. Your provider will monitor how well Opdualag (nivolumab / relatlimab) is working for you based on your skin lesions, scan results, and your cancer symptoms. If you do experience immune-related side effects, you might have to pause or stop taking Opdualag (nivolumab / relatlimab). It’s important to follow up with your provider regularly to track your progress with Opdualag (nivolumab / relatlimab) treatment. In general, people with melanoma take Opdualag (nivolumab / relatlimab) as long as it’s working to treat their cancer and they’re not having any serious side effects.
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              What are the risks and warnings for Opdualag (nivolumab / relatlimab)?

              Opdualag (nivolumab / relatlimab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Immune-related side effects

              Side effects from immunotherapy are typically called immune-related adverse events (irAEs). They happen when the immune system becomes too active and doesn’t just attack cancer cells; it attacks healthy cells, too. These side effects can happen anywhere in your body. They can be mild or very serious. And, they can happen at any time during treatment. Some of these side effects, like changes in lab values that show how well your liver and kidneys are working, might not cause noticeable symptoms. You’ll need blood tests done often so your provider can monitor for those side effects closely. But you might notice certain other immune-related side effects, like diarrhea, skin rash, or shortness of breath. Call your provider right away if you experience any of these symptoms. You might need to pause or stop Opdualag (nivolumab / relatlimab) and take a corticosteroid depending on how severe your symptoms are.

              risk-warning

              Infusion reactions

              Rarely, people taking Opdualag (nivolumab / relatlimab) have experienced severe reactions during their infusion. If you feel itchy or warm, have trouble breathing, feel nauseous, or suddenly have a fast heart rate while receiving Opdualag (nivolumab / relatlimab), let your nurse know right away. Most of the time, giving the infusion slower can help. But sometimes, having a serious reaction means that you shouldn’t take Opdualag (nivolumab / relatlimab) again to avoid having another one in the future.

              risk-warning

              Stem cell transplant complications

              Risk factors: People who’ve received a stem cell (bone marrow) transplant

              Some people who’ve taken immunotherapy medications like Opdualag (nivolumab / relatlimab) and who’ve also had a stem cell transplant have experienced serious problems like graft-versus-host-disease. If you’ve taken an immunotherapy medication like Opdualag (nivolumab / relatlimab) and have also had a stem cell transplant, your provider will follow up with you closely for signs and symptoms of these problems, such as nausea, vomiting, stomach pain, and rash.

              risk-warning

              Harm to unborn baby

              Risk factors: Pregnancy

              Opdualag (nivolumab / relatlimab) might harm an unborn baby or raise the risk for miscarriage (pregnancy loss) when taken during pregnancy. Because of these risks, if you’re a female who can get pregnant, you should use birth control while taking Opdualag (nivolumab / relatlimab) and for 5 months after the last dose. Let your provider know right away if you become pregnant while taking Opdualag (nivolumab / relatlimab).

              dosage

              Opdualag (nivolumab / relatlimab) dosage forms

              Typical dosing for Opdualag (nivolumab / relatlimab)

              People ages 12 years and older (who weigh at least 40 kg):

              • The typical dose of Opdualag is 480 mg of nivolumab and 160 mg of relatlimab every 4 weeks. It’s given as an intravenous (IV) infusion that includes both medications given at the same time.

              alternatives

              What are alternatives to Opdualag (nivolumab / relatlimab)?

              There are a number of medications that your doctor can prescribe in place of Opdualag (nivolumab / relatlimab). Compare a few possible alternatives below.
              images

              Opdualag (nivolumab / relatlimab) images

              yellow - Opdualag 240mg-80mg / 20mL Solution for Infusion
              This medicine is Yellow Vial.yellow - Opdualag 240mg-80mg / 20mL Solution for Infusion

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              References

              Best studies we found

              American Cancer Society. (n.d.). Stem cell or bone marrow transplant.

              American Cancer Society. (2020). What are infusion or immune reactions?

              Be the Match. (n.d.). Graft-versus-host disease basics.

              View All References (9)

              Be the Match. (n.d.). GVHD signs and symptoms.

              Conroy, M., et al. (2022). Immune-related adverse events and the balancing act of immunotherapy. Nature Communications.

              E.R. Squibb & Sons, L.L.C. (2022). Opdualag- nivolumab and relatlimab-rmbw injection [package insert]. DailyMed.

              Graydon, C. G., et al. (2021). LAG3’s enigmatic mechanism of action. Frontiers in Immunology.

              Institute for Quality and Efficiency in Health Care. (2020). How does the immune system work?

              Han, Y., et al. (2020). PD-1/PD-L1 pathway: Current researches in cancer. American Journal of Cancer Research.

              National Comprehensive Cancer Network. (2022). Immunotherapy side effects: Immune checkpoint inhibitors.

              National Comprehensive Cancer Network. (2023). Melanoma.

              National Comprehensive Cancer Network. (2022). Understanding immunotherapy side effects.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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