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testosterone undecanoate

Generic Kyzatrex
Used for Testosterone Replacement
Used for Testosterone Replacement

Kyzatrex (testosterone undecanoate) is an oral medication used to treat adult males with a condition called hypogonadism, meaning they have low or no testosterone. It comes as a convenient capsule that's typically taken by mouth twice a day (once in the morning and once in the evening). The most common side effect of this medication is high blood pressure. Kyzatrex (testosterone undecanoate) is available as a brand-name medication only; there are currently no generic versions on the market.

Last reviewed on August 29, 2023
Kyzatrex (testosterone undecanoate) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Kyzatrex (testosterone undecanoate)?

What is Kyzatrex (testosterone undecanoate) used for?

How Kyzatrex (testosterone undecanoate) works

Testosterone is a hormone that your body makes. It's the main sex hormone in males and is responsible for developing male sex organs. Testosterone also plays a role in maintaining other body functions, such as muscle growth, sex drive, and sperm production.

Some males have low testosterone because of certain medical conditions. Kyzatrex (testosterone undecanoate) works by raising testosterone in the body to healthy levels.

Are you looking for information on Jatenzo (testosterone undecanoate) oral capsule, Tlando (testosterone undecanoate) oral capsule, or Aveed (testosterone undecanoate) injection instead?

Drug Facts

Common BrandsKyzatrex, Undecatrex
Drug ClassTestosterone replacement
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Kyzatrex (testosterone undecanoate)?

Kyzatrex (testosterone undecanoate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

High blood pressure with risk of heart attack or stroke

  • Risk factors: High blood pressure | Heart problems | High blood sugar | Obesity

    Kyzatrex (testosterone undecanoate) can cause high blood pressure that raises the risk of serious problems, such as heart attack, stroke, or sudden cardiac (heart-related) death. This is more likely to occur in people who already have heart problems or have risk factors for heart problems. Your provider will check your blood pressure before you begin taking Kyzatrex (testosterone undecanoate) and periodically after you start or if there's a change in your dose. They'll probably also ask you to check your blood pressure regularly at home. If you develop high blood pressure, your provider might ask you to start blood pressure medication. If your blood pressure still remains high, you might need to stop taking Kyzatrex (testosterone undecanoate).

    Let your provider know and get emergency help right away if you experience symptoms of heart problems, such as:

    Stroke: sudden numbness or weakness on one side of your body, sudden confusion, trouble speaking, difficulty maintaining balance
    Heart attack: dizziness, tiredness, tightness or pain in the chest, heartburn, trouble breathing, sweating, anxiety

    risk-warning

    High red blood cell count

    Kyzatrex (testosterone undecanoate) can cause a high red blood cell count. This can raise the risk for blood clots to develop that can possibly lead to strokes and heart attacks. Your provider will order blood tests every 3 months to check that your red blood cell count is healthy. Get emergency help right away if you have chest pain, cold sweats, left arm pain, difficulty breathing, trouble walking or speaking, or weakness on one side of the body, as you might have to stop taking the medication.

    risk-warning

    Blood clots

    Kyzatrex (testosterone undecanoate) can cause life-threatening blood clots in your legs or lungs. Symptoms of a blood clot in the legs include leg pain, swelling, or redness. Symptoms of a blood clot in the lungs include difficulty breathing or chest pain. Let your provider know if you have any of these symptoms and seek medical help right away, as you might have to stop the medication.

    risk-warning

    Potential for misuse, dependency, and addiction

    • Risk factors: Taking more Kyzatrex (testosterone undecanoate) than prescribed | Taking Kyzatrex (testosterone undecanoate) with other testosterones

      Kyzatrex (testosterone undecanoate) is a controlled substance because it has a risk of misuse, dependency, and addiction, especially if you use higher doses than prescribed or use it with other testosterones. Misusing Kyzatrex (testosterone undecanoate) can cause serious heart and mental health problems. These problems can include heart attack, heart failure, stroke, liver problems, depression, delusions, hallucinations, and aggression. Dependency is when you rely on the medication to function normally and have withdrawal symptoms, such as depression, trouble sleeping (insomnia), and lowered sex drive, when you lower the dose or stop the medication suddenly.

      Continued misuse of Kyzatrex (testosterone undecanoate) can lead to addiction. Addiction can cause behaviors, such as taking a higher dose than prescribed, spending a lot of time trying to get the medication when there are problems with availability, prioritizing medication use over other responsibilities, and having trouble stopping the medication even if you want to stop. Remember to take Kyzatrex (testosterone undecanoate) as prescribed to lower the risk of misuse, dependency, and addiction.

      risk-warning

      Worsening symptoms of enlarged prostate and potential risk of prostate cancer

      • Risk factors: History of enlarged prostate

        Taking Kyzatrex (testosterone undecanoate) can worsen certain symptoms in people with an enlarged prostate, or benign prostatic hyperplasia (BPH). Let your provider know if you experience any changes in your urinary routine, such as more urination at night, feeling like you need to urinate more often or immediately, trouble urinating, accidentally urinating, or urinating slowly.

        Kyzatrex (testosterone undecanoate) can also raise your risk of prostate cancer. Your provider might have you get occasional blood tests and physical check-ups before and during treatment. Kyzatrex (testosterone undecanoate) isn't recommended if you have prostate cancer because it might worsen your cancer.

        risk-warning

        Possible liver problems

        Using certain forms of testosterone, such as methyltestosterone and testosterone enanthate intramuscular injection, for long periods of time can cause life-threatening liver problems. While Kyzatrex (testosterone undecanoate) isn't known to cause liver problems, it's important to be aware of this risk. Let your provider know if you're experiencing stomach pain, light-colored stools, dark urine, or if your skin or the whites of your eyes turn yellow. You might need to stop the medication.

        risk-warning

        Potential risks to your ability to have a baby

        • Risk factors: Taking higher doses of Kyzatrex (testosterone undecanoate)

          Kyzatrex (testosterone undecanoate) can lower the amount of sperm you make, which can make it harder for you to have a baby. This is more likely to happen when using higher doses of Kyzatrex (testosterone undecanoate). Because this might become permanent, talk to your provider if you're trying to have a baby.

          risk-warning

          Swelling in the legs or arms (edema)

          • Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids

            Taking Kyzatrex (testosterone undecanoate) can cause your body to hold onto more salt and water, which can lead to swelling in your legs or arms and sudden weight gain. This is more likely to happen if you're also taking other medications that cause swelling, such as corticosteroids (e.g., prednisone, methylprednisolone (Medrol)). Swelling can be more serious in people with heart, liver, or kidney conditions. Talk to your provider if you have any of these symptoms because you might need to stop Kyzatrex (testosterone undecanoate) or take other medications (e.g., water pills or diuretics) to help with this problem.

            risk-warning

            Breathing problems during sleep (sleep apnea)

            • Risk factors: History of sleep apnea | History of obesity | History of lung problems

              Kyzatrex (testosterone undecanoate) can worsen symptoms in people who have breathing problems while they sleep. This is more likely to happen to people who also have a history of obesity or lung conditions. Talk to your provider if you experience more daytime sleepiness or if your partner notices that you stop breathing in your sleep more often.

              risk-warning

              High calcium in the blood

              • Risk factors: History of cancer | Taking other medications that cause high calcium in the blood

                Kyzatrex (testosterone undecanoate) can raise calcium levels in the blood, especially in people with cancer. Too much calcium can lead to muscle weakness, thirst, bone pain, and kidney problems such as frequent urination. During treatment with Kyzatrex (testosterone undecanoate), your provider might have you get regular blood tests to make sure your calcium levels are within the normal range.

                More on Kyzatrex (testosterone undecanoate) warnings

                basics-icon

                What are the side effects of Kyzatrex (testosterone undecanoate)?

                The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                Common Side Effects

                • High blood pressure (3%)

                Other Side Effects

                • Faster heart rate
                • Headache
                • Diarrhea
                • Constipation
                • Joint pain
                • Swelling in the arms and legs

                Serious Side Effects

                Contact your healthcare provider immediately if you experience any of the following.
                • Heart attack: chest pain, cold sweats, left arm pain, trouble breathing
                • Stroke: face drooping; weakness on one side of the body; trouble seeing, walking, or speaking
                • Blood clots: swelling or pain in legs, trouble breathing, chest pain, cough
                • Liver damage: stomach pain, nausea, vomiting, yellowing of the skin or the whites of the eyes, light-colored stools, dark urine, weight loss
                • Withdrawal symptoms: depression, tiredness, restlessness, irritability, lack of appetite, trouble sleeping, lower sex drive

                Source: DailyMed

                The following side effects have also been reported

                Side effects that you should report to your care team as soon as possible:

                • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
                • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
                • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
                • Increase in blood pressure
                • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
                • Mood swings, irritability, or hostility
                • Prolonged or painful erection
                • Sleep apnea—loud snoring, gasping during sleep, daytime sleepiness
                • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
                • Swelling of the ankles, hands or feet
                • Thoughts of suicide or self-harm, worsening mood, feelings of depression

                Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

                pros-and-cons

                Pros and cons of Kyzatrex (testosterone undecanoate)

                thumbs-up

                Pros

                Works well to replace testosterone in your body

                Conveniently comes as a capsule that you swallow

                Dose can be adjusted based on your testosterone levels

                thumbs-down

                Cons

                Can cause high blood pressure, which can raise your risk of serious heart conditions

                Requires regular blood tests to check testosterone and nutrient levels

                pharmacist-tips

                Pharmacist tips for Kyzatrex (testosterone undecanoate)

                pharmacist
                • You'll typically take Kyzatrex (testosterone undecanoate) twice daily, in the morning and the evening, with food. Taking Kyzatrex (testosterone undecanoate) with food helps it absorb into your system better, which will give you a better response from the medication.

                  • Follow your provider's instructions when taking Kyzatrex (testosterone undecanoate). This medication is only FDA approved for treating low testosterone in males with specific medical conditions. Using it differently can result in severe side effects like heart issues, stroke, depression, hallucinations, and delusions.

                    • Kyzatrex (testosterone undecanoate) can often cause the breast area in males to become bigger, painful, or tender. This might continue throughout treatment. Let your provider know if this becomes bothersome.

                      • Regularly check your blood pressure while using Kyzatrex (testosterone undecanoate), since the medication can raise your blood pressure. If your blood pressure becomes too high, your healthcare provider might suggest adding a blood pressure medication to lower it. Your provider might have you stop taking Kyzatrex (testosterone undecanoate) if it becomes difficult to manage your blood pressure.

                        • If you have diabetes, talk to your provider about whether you need to check your blood sugar more often while taking Kyzatrex (testosterone undecanoate). This medication can lower your blood sugar, especially if you take insulin. Make sure you know how to treat low blood sugar if you experience symptoms like shakiness, sweating, fast heartbeat, and confusion. Also contact your provider if this happens because you might require changes to your medications.

                          • If you're taking blood thinners, like warfarin (Coumadin), let the provider who's managing your blood thinner treatment know that you're taking Kyzatrex (testosterone undecanoate). Taking Kyzatrex (testosterone undecanoate) together with blood thinners can cause you to bleed more easily. Your provider might monitor your blood-clotting time more often when you're taking this medication. Tell your provider if you experience bleeding that takes longer to stop, bruising, blood in your urine, or dark stools, as the dose of your blood thinner might need to be adjusted.

                            • Because Kyzatrex (testosterone undecanoate) can cause high blood pressure, this raises your risk for heart attacks and strokes. Many prescription and over-the-counter medications can also raise your blood pressure. Before starting any new medications, it's important to check with your provider or pharmacist about any interactions.

                              faqs

                              Frequently asked questions about Kyzatrex (testosterone undecanoate)

                              How long does it take Kyzatrex (testosterone undecanoate) to work?
                              Kyzatrex (testosterone undecanoate) can begin to raise your testosterone levels soon after you start treatment. But it might take several weeks for your healthcare provider to help you figure out the right dose that works best for you. Your provider will order labs to measure your testosterone levels at least one week after you start Kyzatrex (testosterone undecanoate). And depending on these results, they might need to change the dose. Then, you'll wait at least another week after each dose change to get tested again to see how the treatment is working for you.
                              How well does Kyzatrex (testosterone undecanoate) work?
                              Pretty well. In clinical studies, Kyzatrex (testosterone undecanoate) raised testosterone levels to a healthy range in 96% of males after 3 months of treatment. But everyone will respond to the medication differently. So if you have questions about how well Kyzatrex (testosterone undecanoate) will work for you, it's best to discuss with your provider.
                              What's the difference between Kyzatrex (testosterone undecanoate) and Jatenzo (testosterone undecanoate)?
                              Kyzatrex (testosterone undecanoate) and Jatenzo (testosterone undecanoate) both have the same active ingredient, testosterone undecanoate. But it's important to note that each brand-name medication contains a different amount of testosterone undecanoate in its capsule, so the dosage isn't the same. You can't substitute one brand-name medication for another. Your dose for each of these medications will be adjusted according to your testosterone levels. Talk to your provider to see which medication is right for you.
                              What's the difference between Kyzatrex (testosterone undecanoate) and Aveed (testosterone undecanoate)?
                              Kyzatrex (testosterone undecanoate) and Aveed (testosterone undecanoate) are both testosterone medications used to treat low testosterone in males, but they're taken differently. Kyzatrex (testosterone undecanoate) is a capsule that's taken by mouth twice a day. On the other hand, Aveed (testosterone undecanoate) injection is given in the buttock muscle at your provider’s office on day 1 of therapy, 4 weeks later, and then every 10 weeks. Discuss with your provider about which medication is best for you.
                              Can Kyzatrex (testosterone undecanoate) treat age-related low testosterone?
                              No. Kyzatrex (testosterone undecanoate) isn't approved to treat age-related low testosterone. Instead, it's specifically FDA approved to treat low testosterone caused by certain medical conditions, like genetic issues, testes infection, or chemotherapy effects. Talk to your provider if you're unsure whether Kyzatrex (testosterone undecanoate) is right for you.
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                              dosage

                              Kyzatrex (testosterone undecanoate) dosage forms

                              Typical dosing for Kyzatrex (testosterone undecanoate)

                              The typical starting dose is 200 mg by mouth twice daily (once in the morning and once in the evening), with food. Your provider might adjust your dose based on the testosterone levels in your blood. The typical maintenance dose ranges from 100 mg once daily to 400 mg twice daily.

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                              contraindications-icon

                              Kyzatrex (testosterone undecanoate) contraindications

                              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Kyzatrex (testosterone undecanoate) will not be safe for you to take.
                              • Breast cancer or prostate cancer

                              • Currently pregnant

                              • Low testosterone levels not caused by anatomical or genetic causes (for example, age-related low testosterone)

                              alternatives

                              What are alternatives to Kyzatrex (testosterone undecanoate)?

                              There are a number of medications that your doctor can prescribe in place of Kyzatrex (testosterone undecanoate). Compare a few possible alternatives below.
                              Kyzatrex (testosterone undecanoate)
                              Used for:
                              $968.20 Lowest GoodRx priceView Prices
                              Used for:
                              • Low testosterone levels from certain medical conditions

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                              Kyzatrex (testosterone undecanoate) images

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                              This medicine is White Capsule Imprinted With "Mp200".White Mp200 - Undecatrex 200mg Capsule

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                              References

                              Best studies we found

                              Marius Pharmaceuticals. (2023). Kyzatrex- testosterone undecanoate capsule, liquid filled [package insert]. DailyMed.

                              McBride, J. A., et al. (2016). Testosterone deficiency in the aging male. Therapeutic Advances in Urology.

                              MedlinePlus. (2022). Hypogonadism.

                              View All References (2)

                              White, W. B., et al. (2021). Effects of the oral testosterone undecanoate Kyzatrex™ on ambulatory blood pressure in hypogonadal men. Journal of Clinical Hypertension.

                              You and Your Hormones. (2020). Testosterone.

                              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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