The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- High blood pressure (3%)
Less Common Side Effects
- Faster heart rate
- Headache
- Diarrhea
- Constipation
- Joint pain
- Swelling in the arms and legs
Kyzatrex serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: chest pain, cold sweats, left arm pain, trouble breathing
- Stroke: face drooping; weakness on one side of the body; trouble seeing, walking, or speaking
- Blood clots: swelling or pain in legs, trouble breathing, chest pain, cough
- Liver damage: stomach pain, nausea, vomiting, yellowing of the skin or the whites of the eyes, light-colored stools, dark urine, weight loss
- Withdrawal symptoms: depression, tiredness, restlessness, irritability, lack of appetite, trouble sleeping, lower sex drive
Source: DailyMed
The following Kyzatrex side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- Increase in blood pressure
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Mood swings, irritability, or hostility
- Prolonged or painful erection
- Sleep apnea—loud snoring, gasping during sleep, daytime sleepiness
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
- Swelling of the ankles, hands or feet
- Thoughts of suicide or self-harm, worsening mood, feelings of depression
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Acne
- Burping
- Change in sex drive or performance
- Diarrhea
- Unexpected breast tissue growth
- Upset stomach


