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famotidine

Generic Pepcid
Used for Duodenal Ulcer, Gastric Ulcer, GERD, Heartburn

Famotidine (Pepcid) is a type of acid reducer called a histamine-2 (H2) antagonist. It helps treat problems caused by too much stomach acid. Over-the-counter famotidine (Pepcid or Pepcid AC) can help with heartburn in people who are 12 and up. Prescription-only famotidine is for people with more ongoing stomach acid problems and stomach or gut ulcers. This medication is taken by mouth once or twice a day. It usually starts to work within an hour and lasts several hours. Side effects include headache, dizziness, and constipation.

Reviewed by:
reviewerRobert Chad Hakim, PharmD, BCCCP
reviewerCydnee Ng, PharmD
Last reviewed on January 23, 2026
basics-icon

What is Famotidine (Pepcid)?

What is Famotidine (Pepcid) used for?

How Famotidine (Pepcid) works

Famotidine (Pepcid) is a histamine-2 (H2) antagonist. It works by blocking proteins in your stomach called H2 receptors. This lowers the amount of acid that's made and released in the stomach.

When does Famotidine (Pepcid) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsPepcid, Pepcid AC, Pepcid AC Maximum Strength
Drug ClassHistamine H2 antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription or over-the-counter
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Side effects of Famotidine (Pepcid)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Fever
  • Fatigue
  • Nausea
  • Vomiting
  • Upset stomach
  • Dry mouth
  • Dry skin
  • Itchy skin

Source: DailyMed

The following Famotidine (Pepcid) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Abdominal pain

back, leg, or stomach pain

bleeding or crusting sores on lips

blistering, burning, redness, scaling, or tenderness of skin

blisters on palms of hands and soles of feet

changes in vision or blurred vision

confusion

coughing or difficulty in swallowing

dark-colored urine

dizziness

fainting

fast, pounding, or irregular heartbeat

fever and/or chills

flu-like symptoms

general feeling of discomfort or illness

hives

inflammation of blood vessels

joint pain

light-colored stools

mood or mental changes, including anxiety, agitation, confusion, hallucinations (seeing, hearing, or feeling things that are not there), mental depression, nervousness, or severe mental illness

muscle cramps or aches

nausea, vomiting, or loss of appetite

pain

peeling or sloughing of skin

red or irritated eyes

shortness of breath

skin rash or itching

slow heartbeat

sore throat

sores, ulcers, or white spots on lips, in mouth, or on genitals

sudden difficult breathing

swelling of face, lips, mouth, tongue, or eyelids

swelling of hands or feet

swollen or painful glands

tightness in chest

troubled breathing

unusual bleeding or bruising

unusual tiredness or weakness

unusually slow or irregular breathing

wheezing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

Constipation

decrease in sexual desire

decreased sexual ability (especially in patients with Zollinger-Ellison disease who have received high doses of cimetidine for at least 1 year)

diarrhea

difficult urination

dizziness

drowsiness

dryness of mouth or skin

headache

increased or decreased urination

increased sweating

loss of hair

ringing or buzzing in ears

runny nose

swelling of breasts or breast soreness in females and males

trouble in sleeping

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. All of the H2-blockers are similar, so any of the above side effects may occur with any of these medicines.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Famotidine (Pepcid)

Pros

Cons

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Pharmacist tips for Famotidine (Pepcid)

pharmacist

General tips for famotidine (Pepcid):

  • Swallow famotidine (Pepcid) tablets whole with a full glass of water. Don't chew them because this can change how the medication works in your body. If you have trouble swallowing, talk to a healthcare professional about your options.
  • If you need more or better relief, talk to a healthcare professional for help. They might recommend a different kind of acid reducer for you. They can make sure it's safe to take other acid reducers before you do this on your own.
  • Ask a pharmacist to check that famotidine (Pepcid) is safe to take with your other medications. Famotidine (Pepcid) can change how well your body can absorb some medications. This includes certain antiviral and antifungal medications.

Tips for over-the-counter famotidine (Pepcid):

  • You can take famotidine (Pepcid) with or without food. But for preventing heartburn, it works best when you take it 10 to 60 minutes before eating or drinking something that might cause heartburn.
  • Ask a healthcare professional if it's safe for you to take famotidine (Pepcid) if you've had heartburn for more than 3 months. Also ask if you have chest pain often. These can be signs of a serious problem that needs to get checked out.
  • Before taking famotidine (Pepcid), call a healthcare professional if you have chest or shoulder pain, or pain that spreads to your arms or neck. Get help right away if this pain or heartburn happens with trouble breathing, wheezing, sweating, or dizziness. These can be signs of a heart attack, which needs emergency care.
  • Talk to a healthcare professional before taking famotidine (Pepcid) if you have weight loss you can't explain, nausea, vomiting, or stomach pain. Get medical help right away if you vomit blood or have black or bloody stools. These can be signs of a serious problem that needs medical care.
  • If you have kidney problems, ask a healthcare professional if famotidine (Pepcid) is safe for you. You might be at higher risk of certain side effects.
  • Stop taking famotidine (Pepcid) and talk to a healthcare professional if your heartburn doesn't get better or gets worse. Also stop and get medical advice if you feel you need to take it for more than 14 days in a row. You might need to get checked out to see what's causing your symptoms.

Tips for prescription famotidine:

  • Take the medication with or without food. If it's upsetting your stomach, try taking it with food next time to help.
  • For famotidine once daily: Take the medication once daily before bedtime.
  • For famotidine twice daily: Take the medication in the morning and then later before bedtime.

Tips for the liquid form of prescription famotidine:

  • The pharmacist will make the liquid form of famotidine for you when you pick it up from the pharmacy. They'll give you a dosing cup or an oral syringe to measure your dose. Don't use kitchen spoons because they aren't accurate and you could take the wrong dose.
  • Before each time you take liquid famotidine, shake the bottle well for 5 to 10 seconds first. This makes sure the medication is mixed well.
  • Keep the liquid medication in its original bottle at room temperature for up to 30 days. The pharmacist will write the expiration date on the bottle. After that date, throw the bottle away, even if there's medication left inside.
faq-icon

Common questions about Famotidine (Pepcid)

Famotidine (Pepcid) starts to work within an hour. The medication's full effect can take up to 3 hours to kick in.

No, famotidine (Pepcid) isn't a proton pump inhibitor (PPI). It's a different type of medication called a histamine-2 (H2) antagonist. Both lower stomach acid, but they work in different ways. In general, H2 antagonists like famotidine (Pepcid) work faster and can help with heartburn within a few hours. PPIs can take a couple days to work, so they're not usually used for quick relief. Talk to a healthcare professional to learn more about what kind of acid reducer is right for you.

Don't take famotidine (Pepcid) with omeprazole (Prilosec) or pantoprazole (Protonix) unless a healthcare professional says it's okay. Omeprazole (Prilosec) or pantoprazole (Protonix) usually works well on their own. But in some cases, your primary care provider might add famotidine (Pepcid). For example, taking famotidine (Pepcid) at bedtime might help if you still have heartburn at night. Your primary care provider can help decide the best option for you.

You might be able to take calcium carbonate (Tums) with famotidine (Pepcid). But ask a healthcare professional first. Calcium carbonate (Tums) works in just a few minutes, so it can help while you wait for famotidine (Pepcid) to start working, which can take about an hour. Calcium carbonate (Tums) might also help if you have heartburn between your famotidine (Pepcid) doses. Tell your primary care provider if you've been taking calcium carbonate (Tums), famotidine (Pepcid), or both for more than 2 weeks. You might need a better treatment option.

Yes, constipation can be a side effect of famotidine (Pepcid). Be sure to drink plenty of water and fiber rich foods to help prevent constipation. These tips might be helpful for managing heartburn, too. Talk to your primary care provider if you get constipated while taking famotidine (Pepcid) and it isn't getting better with time. They can recommend management strategies or a change in your heartburn treatment.

Yes, diarrhea can happen with famotidine (Pepcid). If you have diarrhea, be sure to stay hydrated throughout the day. Try avoiding spicy or greasy foods, which can also be triggers for heartburn. Talk to your primary care provider if the diarrhea is hard to handle. They can suggest other ways to help, such as over-the-counter medications or a different heartburn treatment.

For over-the-counter famotidine (Pepcid), taking 40 mg twice a day might not be safe for occasional mild heartburn. This might raise the risk of side effects. For prescription famotidine, taking 40 mg twice a day is an option only for people with erosive esophagitis from GERD. Only take 40 mg twice a day if a healthcare professional prescribed it to you this way. If you feel like your current dose isn't helping enough, talk to your primary care provider before taking any more.

If you're pregnant, talk to a healthcare professional before taking famotidine (Pepcid). There isn't a clear link between this medication and birth defects or pregnancy problems like early labor. The American Academy of Family Physicians (AAFP) says that famotidine (Pepcid) is a "probably safe" option. But in general, more data is needed to be sure. Healthcare professionals usually recommend trying antacids like calcium carbonate (Tums) and changing your diet first. Your care team can help you choose the safest option for you.

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Risks and warnings for Famotidine (Pepcid)

Famotidine (Pepcid) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Confusion and other side effects related to the nervous system in some people

  • Risk factors: Older adults | People with kidney problems

Some older adults taking famotidine (Pepcid) have felt confused, tense, restless, or weak. Other side effects included seizures and hallucinations (seeing things that aren't real).

These side effects have also happened in some people with kidney problems. When the kidneys don't work well, famotidine (Pepcid) can build up in the body and raise the risk of side effects. If you have kidney problems, tell your prescriber so they can adjust your dose to keep you safe.

Call your care team right away if you notice any of these side effects while taking famotidine (Pepcid).

Masking of possible stomach cancer

Heartburn can sometimes be a sign of a more serious stomach problem, like stomach cancer. Medications like famotidine (Pepcid) can relieve heartburn and hide this warning sign.

If your heartburn doesn't fully go away or comes back after you've finished famotidine (Pepcid), talk to your primary care provider. They might suggest some lab tests to check for a more serious gut problem.

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Famotidine (Pepcid) dosage

The average cost for 60 tablets of 20mg of Famotidine (Pepcid) is $10.45 with a free GoodRx coupon. This is 90.43% off the average retail price of $109.24.
bottle of oral suspensionBottle of oral suspension
DosageQuantityPrice as low asPrice per unit
50ml of 40mg/5ml1 bottle$19.59$19.59
100ml of 40mg/5ml1 bottle$36.30$36.30
150ml of 40mg/5ml1 bottle$40.05$40.05
tabletTablet
DosageQuantityPrice as low asPrice per unit
20mg60 tablets$10.45$0.17
40mg90 tablets$15.68$0.17
10mg30 tablets$6.50$0.22

Typical dosage for Famotidine (Pepcid)

Over-the-counter famotidine (Pepcid AC)

  • 10 mg tablets - for people 12 years and older
    • Heartburn prevention: The typical dose is 10 mg by mouth 10 to 60 minutes before eating food or drinking beverages that can cause heartburn. Don't take more than 2 tablets (20 mg) in a 24-hour period.
    • Heartburn relief: The typical dose is 10 mg by mouth when you feel heartburn symptoms. Don't take more than 2 tablets (20 mg) in a 24-hour period.
  • 20 mg tablets - for people 12 years and older
    • Heartburn prevention: The typical dose is 20 mg by mouth 15 to 60 minutes before eating food or drinking beverages that can cause heartburn. Don't take more than 2 tablets (40 mg) in a 24-hour period.
    • Heartburn relief: The typical dose is 20 mg by mouth when you feel heartburn symptoms. Don't take more than 2 tablets (40 mg) in a 24-hour period.

Prescription famotidine

  • Tablets (20 mg or 40 mg)

    • People weighing 88 lbs or more
      • Stomach ulcer: The typical dose is 40 mg by mouth once daily for up to 8 weeks.
      • Intestinal (gut) ulcer: The typical dose is 40 mg by mouth once daily or 20 mg by mouth twice daily for up to 8 weeks.
      • Heartburn or GERD: The typical dose is 20 mg by mouth twice daily for up to 6 weeks.
      • Erosive esophagitis due to GERD: The typical dose is 20 mg or 40 mg by mouth twice daily for up to 12 weeks.
      • Lowering the risk of another gut ulcer (adults only): The typical dose is 20 mg by mouth daily for 1 year or as directed by your prescriber.
      • Other conditions that cause too much stomach acid (adults only): The typical starting dose is 20 mg by mouth every 6 hours. Your prescriber will adjust your dose based on your needs. The maximum dose is 160 mg every 6 hours.

  • Liquid suspension (40 mg/5 mL)

    • Adults

      • Stomach ulcer: The typical dose is 40 mg by mouth once daily for up to 8 weeks.
      • Gut ulcer: The typical dose is 40 mg by mouth once daily or 20 mg by mouth twice daily for up to 8 weeks.
      • Lowering the risk of another gut ulcer: The typical dose is 20 mg by mouth daily for 1 year or as directed by your prescriber.
      • Heartburn or GERD: The typical dose is 20 mg by mouth twice daily for up to 6 weeks.
      • Erosive esophagitis due to GERD: The typical dose is 20 mg or 40 mg by mouth twice daily for up to 12 weeks.
      • Other conditions that cause too much stomach acid: The typical starting dose is 20 mg by mouth every 6 hours. Your prescriber will adjust your dose based on your needs. The maximum dose is 160 mg every 6 hours.

    • Children ages 1 year and older

      • Stomach or gut ulcer: The typical starting dose is 0.5 mg/kg of body weight by mouth once daily, or 0.25 mg/kg twice daily. The prescriber can adjust the dose if needed. The maximum dose is 1 mg/kg once daily at bedtime, or 0.5 mg/kg twice daily. Don't take more than 40 mg daily. Take for a total of 8 weeks.
      • Heartburn or GERD: The typical dose is 0.5 mg/kg of body weight by mouth twice daily for 6 to 12 weeks. The maximum dose is 40 mg twice daily.

    • Children ages 3 months to less than 1 years old

      • Heartburn or GERD: The typical starting dose 0.5 mg/kg of body weight by mouth twice daily for up to 8 weeks. The maximum dose is 1 mg/kg twice daily. Don't take more than a total of 40 mg daily.

    • Children from birth to less than 3 months old

      • Heartburn or GERD: The typical starting dose 0.5 mg/kg of body weight by mouth once daily for up to 8 weeks. The maximum dose is 1 mg/kg once daily.

For prescription famotidine, your dose might differ if you have kidney problems.

Prescription famotidine is also available as an injection that's given into the vein for people in the hospital.

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Interactions between Famotidine (Pepcid) and other drugs

Famotidine (Pepcid) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Famotidine (Pepcid). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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Famotidine (Pepcid) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Famotidine (Pepcid) will not be safe for you to take.

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What are alternatives to Famotidine (Pepcid)?

There are a number of medications that your doctor can prescribe in place of Famotidine (Pepcid). Compare a few possible alternatives below.
Famotidine (Pepcid)
Used for:
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Used for:
$22.03Lowest GoodRx priceView prices
Used for:

For adults only:

For adults and children:

  • Gastroesophageal reflux disease (GERD)
  • Inflamed esophagus due to GERD
$8.60Lowest GoodRx priceView prices
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Omeprazole and famotidine both treat GERD symptoms, like heartburn. Learn how they differ so you can choose the best medication for you.
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Famotidine (Pepcid) images

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References

Best studies we found

Albertsons Companies. (2025). FAMOTIDINE tablet [package insert]. DailyMed.

Antunes, C., et al. (2023). Esophagitis. StatPearls.

Ascend Laboratories, LLC. (2025). FAMOTIDINE tablet, film coated [package insert]. DailyMed.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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