Medications for aldosteronism help control your aldosterone levels. They're also used to treat high blood pressure, heart failure, and fluid retention. They work by blocking the effects of aldosterone, a hormone that can cause your body to retain too much salt and water. Common classes include potassium-sparing diuretics such as mineralocorticoid receptor antagonists. Mineralocorticoid receptor antagonists like spironolactone (Aldactone) are usually taken as oral pills.