Zyrtec-D vs. Benadryl for Allergic Rhinitis: Important Differences and Potential Risks.

Key takeaways

Zyrtec-D (cetirizine/pseudoephedrine) and diphenhydramine (Benadryl) are both over-the-counter medications used to treat allergy symptoms, but they have some key differences. Zyrtec-D combines an antihistamine (cetirizine) and a decongestant (pseudoephedrine), making it effective for both allergies and nasal congestion. However, it can cause trouble sleeping if taken too close to bedtime and may raise your blood pressure. Diphenhydramine, on the other hand, is solely an antihistamine and is known for causing significant drowsiness, which makes it useful as a sleep aid. Unlike Zyrtec-D, diphenhydramine is not recommended for long-term use due to potential memory and confusion issues, especially in older adults. Additionally, diphenhydramine can cause hyperactivity in some children and should not be used for sleep in children under 12. Both medications are available in generic forms and come in various dosage forms, but Zyrtec-D requires a photo ID for purchase due to pseudoephedrine regulations.

Zyrtec-D

(cetirizine / pseudoephedrine)

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Diphenhydramine

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Summary for Zyrtec-D

Over-the-counter

Zyrtec-D is a combination medication containing cetirizine (an antihistamine) and pseudoephedrine (a decongestant). It's taken by people ages 12 years and older to relieve allergy symptoms, like runny nose and nasal congestion. This medication comes as an extended-release tablet that's taken by mouth every 12 hours. Zyrtec-D is available as a brand-name and generic medication. Side effects can include trouble sleeping and dry mouth.

Indications for Zyrtec-D

Short-term relief of allergy symptoms in adults and children ages 12 years and older:

Itchy nose or throat
Sneezing
Itchy or watery eyes
Runny or stuffy nose
Sinus congestion or pressure

Pros and Cons for Zyrtec-D

Pros

Starts working within an hour
Easier to take a combination pill instead of two separate pills to treat congestion and other allergy symptoms
Available over the counter (behind the counter)

Cons

Might need to take twice daily
Tablets can't be crushed or chewed and there isn't a liquid version available
Not the safest choice if you have certain conditions, like heart problems and trouble urinating

Common Side Effects for Zyrtec-D

Trouble sleeping (4%)
Dry mouth(4%)

Warnings for Zyrtec-D

Fast heart rate and high blood pressure
Worsening of certain medical conditions
Accidentally taking too much medication

Summary for Benadryl

Over-the-counter

Diphenhydramine, also known by the brand name Benadryl, is an over-the-counter antihistamine used to relieve allergy or common cold symptoms in adults and children. It comes as pills and a liquid and is typically taken by mouth every 4 to 6 hours as needed. Because it can make you drowsy, some people also use it as a sleep aid at bedtime. Common side effects include sleepiness, dizziness, and dry mouth.

Indications for Benadryl

Short-term relief of allergy or common cold symptoms (runny nose, sneezing, itchy nose or throat, and itchy or watery eyes) - people 6 years and older
Occasional trouble sleeping - people 12 years and older