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Zioptan vs. Brimonidine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zioptan (tafluprost) and Alphagan P (brimonidine) are both prescription eye drops used to lower high pressure in the eye caused by open-angle glaucoma or ocular hypertension. However, they belong to different medication classes. Zioptan (tafluprost) is a prostaglandin, while Alphagan P (brimonidine) is an alpha agonist. Zioptan is typically used once daily in the evening and comes in single-use containers. In contrast, Alphagan P is used three times daily, about 8 hours apart. Zioptan can cause changes in eye color and eyelash growth, while Alphagan P may lead to dry mouth, headaches, and drowsiness. Additionally, Zioptan is preservative-free, which may be less irritating for some users. Your eye doctor will help you find the right one for you, based on your specific eye health needs, side effect profile, and lifestyle.

Zioptan

(tafluprost)

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Alphagan P

(brimonidine)

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Summary for Zioptan

Prescription only

Zioptan (tafluprost) is an eye drop medication used to treat high pressure in the eye, such as glaucoma. It works as a prostaglandin to help relieve pressure in the eye. Zioptan (tafluprost) is for adults and is used once each night. Side effects include feeling like there's something in the eye, burning, and stinging. Zioptan (tafluprost) is available as a brand-name and now also a generic medication.

Indications for Zioptan

Pros and Cons for Zioptan

Pros

  • A first-choice option for lowering eye pressure
  • Only used once a day
  • Is preservative free, which might be less irritating to the eye

Cons

  • Often causes some eye redness
  • Can permanently darken the color of your eye over time
  • Must use eye drop vials inside the foil pouch within 30 days after opening the pouch

Common Side Effects for Zioptan

  • Eye redness (up to 20%)
  • Eye stinging or irritation (7%)
  • Headache (6%)
  • Itchy eye (5%)

Warnings for Zioptan

  • Darker eyes or eyelids
  • Eyelash changes
  • Eye inflammation
  • Swelling of the retina (macular edema)

Summary for Brimonidine

Prescription only

Alphagan P (brimonidine) is a prescription eye drop that helps lower pressure in the eye and treats glaucoma. It's typically applied three times a day. Some common side effects include blurry vision, slight stinging in the eyes, and headaches. Alphagan P (brimonidine) is available as both a brand name and a generic medication.

Indications for Brimonidine

High pressure in the eye caused by:

Pros and Cons for Brimonidine

Pros

  • Good at treating high eye pressure
  • Start working to lower eye pressure in as quickly as 1 hour
  • Can be stored at room temperature

Cons

  • Can cause dry mouth, headache, and drowsiness
  • Applied 3 times daily
  • Must take out contact lenses out before applying

Common Side Effects for Brimonidine

  • Dry mouth (up to 30%)
  • Red eye (up to 30%)
  • Eye burning and stinging (up to 30%)
  • Headache (up to 30%)
  • Blurry vision (up to 30%)
  • Feeling like there's something in your eye (up to 30%)
  • Sleepiness (up to 30%)
  • Small white patches on the inside of the eyelids (up to 30%)
  • Allergic reactions in the eye (up to 30%)
  • Itchy eyes (up to 30%)

Warnings for Brimonidine

  • Risk of worsening of low blood flow
  • Risk of infections (from contamination)
  • No soft contact lenses
  • Only use in the eye

Prices with our coupons for Zioptan vs. Brimonidine

Price Card Drug Icon
Tafluprost1 carton / 30 single-use containers of 0.0015%
$60.48$233.00
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Price Card Drug Icon
Brimonidine1 eye dropper / 5ml of 0.2%
$12.88$20.99
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