Key takeaways
Abacavir (Ziagen) and Combivir (lamivudine/zidovudine) are both medications used to treat HIV. They belong to the same class of medications called nucleoside reverse transcriptase inhibitors (NRTIs), which work by stopping the HIV virus from making copies of itself. However, they have some differences. Abacavir is a single medication, while Combivir is a combination of two medications, lamivudine and zidovudine. They should each be used with other HIV medications for the treatment of HIV. Abacavir is available as a tablet and oral solution, and it can be taken once or twice a day, depending on the dose. Combivir is taken as a tablet twice a day. Both medications are available in generic forms. Abacavir requires a genetic test before starting due to the risk of a severe allergic reaction, while Combivir can cause blood and muscle problems. Common side effects of abacavir include headache, nausea and rash, whereas Combivir often causes headache, fatigue and runny nose and congestion. Abacavir has fewer drug interactions, but people taking methadone might need a higher dose after starting it. Abacavir requires caution in people with heart or severe liver problems. Combivir is not recommended for people with kidney or liver problems, and it can cause fat loss in certain areas of the body.
