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Xenleta vs. Ceftin

Xenleta (lefamulin) is FDA approved to treat adults with community-acquired bacterial pneumonia (CABP). This medication is a type of antibiotic called a pleuromutilin antibiotic. Xenleta (lefamulin) is a tablet that's taken by mouth twice a day for 5 days. It's also available as an intravenous (IV) infusion that's given by a healthcare professional for 5 to 7 days. Side effects aren't common but can include diarrhea and nausea.

• Community-acquired bacterial pneumonia (CABP) in adults

Xenleta (lefamulin) tablets:

• Diarrhea (12%)
• Nausea (5%)

Xenleta (lefamulin) injection:

• Pain, swollen vein, or other reactions at the injection site (7%)

• Risk for serious abnormal heart rhythm (QT prolongation)
• Harm to an unborn baby
• Diarrhea from Clostridioides difficile infection
• Drug-resistant bacteria

Cefuroxime, also known by its brand name Ceftin, is a cephalosporin antibiotic that treats bacterial infections throughout the body. These infections can include sinus infection, ear infection, and urinary tract infection (UTI), among others. The brand name Ceftin has been discontinued, but generic cefuroxime is still available as a tablet and an injection. The tablets are taken by mouth typically every 12 hours, but the dosage depends on your infection and kidney function. Side effects aren't common, but can include diarrhea, nausea, and vomiting.

Cefuroxime tablets:

• Strep throat
• Tonsil infection
• Ear infection
• Sinus infection
• Lung infection related to long-term bronchitis
• Skin infection
• Urinary tract infection (UTI)
• Gonorrhea
• Lyme disease

Cefuroxime injection:

• Lower respiratory tract infection
• UTI
• Skin infection
• Bone and joint infection
• Bloodstream infection
• Meningitis

• Diarrhea (4%)
• Nausea or vomiting (3%)

• Severe allergic reaction
• Diarrhea from Clostridioides difficile infection
• Possible development of drug-resistant bacteria