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Ethambutol vs. Isoniazid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ethambutol (Myambutol) and isoniazid (Nydrazid) are both antibiotics used to treat tuberculosis (TB), but they have some key differences. Both medications must be taken with other anti-TB antibiotics for treatment of TB infection. Isoniazid can be taken alone for TB prevention. Ethambutol is only available in tablet form, while isoniazid is available in tablet, liquid and injection forms. Ethambutol can cause vision problems, including optic neuritis, which may lead to blindness if not monitored, whereas isoniazid is more likely to cause serious liver injury and nerve problems. Isoniazid requires you to avoid certain foods like cheese and red wine due to potential interactions, while ethambutol does not have such dietary restrictions. Both medications are affordable in their generic forms and require regular monitoring, but isoniazid may also necessitate taking vitamin B6 supplements to prevent nerve issues.

Ethambutol

(Myambutol)

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Isoniazid

 

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Summary for Ethambutol

Prescription only

Ethambutol, also known by its brand name Myambutol, is an antibiotic that's used to treat tuberculosis (TB) for people over 13 years old. It's taken with other TB antibiotics as part of a first-choice treatment plan. Ethambutol (Myambutol) works by stopping TB bacteria from growing and surviving. Your dose is based on your body weight. In general, this antibiotic is taken by mouth once a day. Ethambutol (Myambutol) can cause vision problems as a side effect. You'll need to get your eyes checked periodically while you're taking this medication.

Indications for Ethambutol

Pros and Cons for Ethambutol

Pros

  • One of the main medications used to treat TB
  • Can take with or without food
  • Taken once a day

Cons

  • Must take with other TB antibiotics
  • Risk of vision problems
  • Not approved for children younger than 13 years old

Common Side Effects for Ethambutol

  • Blurry vision
  • Nausea or vomiting
  • Upset stomach
  • Stomach pain
  • Fever
  • Feeling unwell
  • Headache
  • Dizziness

Warnings for Ethambutol

  • Vision problems
  • Liver injury

Summary for Isoniazid

Prescription only

Isoniazid is an antimycobacterial agent for treating and preventing tuberculosis (TB) in children and adults. It's available as a generic oral tablet and solution, usually taken daily or a few times a week, depending on your dose. For treating active TB, you'll likely need to take it along with other TB medications (like rifampin, pyrazinamide, and ethambutol) to prevent antibiotic resistance. Serious side effects include severe liver injury. It's also known to interact with many foods and medications.

Indications for Isoniazid

Pros and Cons for Isoniazid

Pros

  • Is one of the main medications used to treat TB
  • Can be taken by itself for prevention of TB (along with a pyridoxine supplement)
  • Available as an oral tablet and oral solution
  • Available as a lower-cost generic

Cons

  • Can cause serious liver damage
  • Likely will need to take it for many months
  • You might need to take each dose in front of a healthcare professional
  • Interacts with many foods and medications

Common Side Effects for Isoniazid

  • Tingling or numbness in your hands and feet
  • Rise in liver enzymes

Warnings for Isoniazid

  • Liver injury (hepatitis)
  • Interactions

Prices with our coupons for Ethambutol vs. Isoniazid

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Ethambutol60 tablets / 400mg
$26.61$88.21
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Isoniazid30 tablets / 300mg
$12.27$128.86
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