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Compare Sirturo vs. Avelox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sirturo (bedaquiline)
    Moxifloxacin (Avelox)
  • Sirturo (bedaquiline)
    Moxifloxacin (Avelox)

  • Summary of Sirturo vs. Avelox

    Summary for Antitubercular agent
    Prescription only

    Sirturo (bedaquiline) is reserved for treating tuberculosis (TB) that is resistant to other antibiotics. It was FDA-approved under an accelerated process, since there are few options available to treat life-threatening resistant TB lung infection. The medication is also linked to a higher risk of death and heart problems.

    Summary for Fluoroquinolone antibiotic
    Prescription only

    Moxifloxacin (Avelox) is a fluoroquinolone antibiotic. It can treat different types of infections, including certain skin infections and lung infections, in adults. But because moxifloxacin (Avelox) can cause serious side effects, such as tendon rupture and nerve damage, it's usually only prescribed for more serious infections or when safer options aren't available. Moxifloxacin (Avelox) is taken by mouth, typically once daily. Some of the more common side effects of this medication include nausea, diarrhea, and headache. Moxifloxacin is generic only, brand-name Avelox is no longer available.

  • Indications of Sirturo vs. Avelox

    Indications for
    •Tuberculosis (TB) lung infection that is resistant (doesn't respond to) to other anti-TB antibiotics
    Indications for

    Treatment of certain bacterial infections, including:

    •Lung infections (e.g., community acquired pneumonia, chronic bronchitis flare-ups)
    •Skin infections
    •Gut infections
    •Plague
    •Sinus infections

  • Pros and Cons of Sirturo vs. Avelox

    Pros and Const for Antitubercular agent
    Pros
    •Treats multi-drug resistant tuberculosis (MDR-TB), which is a serious health problem with few new antibiotic options
    •Can be given to children as young as 5 years old
    •After the first 2 weeks of taking it daily, you only need to take it 3 times a week.
    •The 20 mg tablet can be dissolved or crushed for people who can't swallow a whole tablet.
    •Can be given through feeding tube
    Cons
    •Each dose requires multiple tablets and should be taken in front of a healthcare provider.
    •Must be taken in combination with at least 3 other anti-TB antibiotics
    •Linked with a higher risk of death, so it should only be used if absolutely needed
    •Not for TB that is latent (non-active) or TB that has spread outside the lungs
    •Very expensive, and not available as a generic
    Pros and Const for Fluoroquinolone antibiotic
    Pros
    •Can take with or without food
    •Only taken once a day
    •Treats many types of infections
    •Might be an option for people who have penicillin allergy
    Cons
    •Not well-studied in children
    •Interacts with a lot of common medications, such as warfarin (Coumadin) and antacids
    •Has many potentially serious side effects and risks (e.g., nerve issues, irregular heartbeat)

  • Common Side Effects of Sirturo vs. Avelox

    Common Side Effects for
    •Nausea (38%)
    •Joint pain (33%)
    •Headache (28%)
    •Coughing up blood (18%)
    •Chest pain (11%)
    •Low appetite (9%)
    •Higher liver enzymes (3-9%)
    •Rash (8%)
    Common Side Effects for
    •Nausea (7%)
    •Diarrhea (6%)
    •Headache (4%)
    •Dizziness (3%)
    •Trouble sleeping (2%)
    •Vomiting (2%)
    •Constipation (2%)
    •Belly pain (2%)

  • Warnings of Sirturo vs. Avelox

    Common Side Effects for
    •Higher risk of death
    •Heart rhythm problems
    •Drug-resistant bacteria
    •Liver damage
    •Drug interactions
    Common Side Effects for
    •Tendon inflammation and rupture
    •Effects on the brain, nerves, and mental health
    •Worsening of myasthenia gravis
    •Heart rhythm problems (QT prolongation)
    •Severe allergic and skin reactions
    •Severe damage to a major blood vessel
    •Severe infectious diarrhea
    •Changes in blood sugar
    •Sun and light sensitivity

  • Prices with our coupons for Sirturo vs. Avelox

    Learn more about Sirturo
    Learn more about Moxifloxacin

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