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Compare Pyrazinamide vs. Mycobutin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Pyrazinamide and Rifabutin (Mycobutin) are both antibiotics, but they belong to different medication classes and have different uses. Pyrazinamide is used to treat active tuberculosis (TB) and is taken with other TB medications like isoniazid and rifampin. Rifabutin, a rifamycin antibiotic, is used to prevent Mycobacterium avium complex (MAC) infection in people with advanced HIV. Both medications come as a lower-cost generic. Pyrazinamide is typically dosed based on body weight, while rifabutin is usually taken as a 300 mg capsule once daily. Pyrazinamide can cause side effects like muscle or joint pain and liver issues and may increase uric acid levels, raising the risk for gout. Rifabutin can change the color of your body fluids, including urine, and may cause low blood cell counts and serious allergic reactions. Pyrazinamide is not recommended for people with severe liver problems or recent gout flares, while rifabutin should not be used if you have active TB. Rifabutin interacts with many medications, so it's important to be sure your prescriber and pharmacist have a complete list of your medications.

  • Pyrazinamide
    Rifabutin (Mycobutin)
  • Pyrazinamide
    Rifabutin (Mycobutin)

  • Summary of Pyrazinamide vs. Mycobutin

    Summary for Antitubercular agent
    Prescription only

    Pyrazinamide is an antibiotic that treats active tuberculosis (TB). It's taken together with other anti-TB medications, such as isoniazid and rifampin. Pyrazinamide can cause side effects like joint or muscle ache, nausea, and vomiting. This medication can also affect the liver and raise your risk for gout. Pyrazinamide is available as a lower-cost generic tablet.

    Summary for Rifamycin antibiotic
    Prescription only

    Rifabutin (Mycobutin) is used to prevent Mycobacterium avium complex (MAC) infection in people with advanced human immunodeficiency virus (HIV). It's available as a capsule that's taken by mouth, typically once daily. The most common side effect of rifabutin (Mycobutin) include temporarily change the color of your teeth, body fluids, and even urine.

  • Indications of Pyrazinamide vs. Mycobutin

    Indications for
    •Treatment of active tuberculosis (TB)
    Indications for
    •Prevention of Mycobacterium avium complex (MAC) disease in people with severe HIV infection

  • Pros and Cons of Pyrazinamide vs. Mycobutin

    Pros and Const for Antitubercular agent
    Pros
    •One of the first-choice medications used to treat active TB
    •Usually taken for 2 months
    •Can take once per day or a few times per week, depending on your dosing schedule
    •Safe for children to take
    Cons
    •Must take with other anti-TB antibiotics
    •Not a good option for people with severe liver problems
    •Can worsen gout and shouldn't be used in people with recent gout flares
    •Only available in tablet form
    Pros and Const for Rifamycin antibiotic
    Pros
    •Helps prevent MAC, a very serious infection, if you have severe HIV
    •Is an option for people who can't take azithromycin or clarithromycin to prevent MAC
    •Can take with or without food
    Cons
    •Isn't a first-choice medication for prevention of MAC in people with HIV
    •Interacts with many medications, including some HIV medications
    •Can change the color of your skin and body fluids, and stain your contact lenses

  • Common Side Effects of Pyrazinamide vs. Mycobutin

    Common Side Effects for
    •Mild joint or muscle ache
    •Nausea
    •Vomiting
    •Loss of appetite
    Common Side Effects for
    •Change in urine color (30%)
    •Low blood cell count (up to 25%)
    •Rash (11%)
    •Higher liver enzymes (7-9%)
    •Nausea (6%)

  • Warnings of Pyrazinamide vs. Mycobutin

    Common Side Effects for
    •Liver injury
    •Gout
    •Caution in people with diabetes
    Common Side Effects for
    •Not for treatment of tuberculosis (TB)
    •Interactions with other medications
    •Serious allergic and skin reactions
    •Eye inflammation
    •Infectious diarrhea
    •Low blood cell counts

  • Prices with our coupons for Pyrazinamide vs. Mycobutin

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    Learn more about Rifabutin

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