Key takeaways
Cariprazine (Vraylar) and bupropion (Wellbutrin XL, Wellbutrin SR) are both prescription medications used to treat mental health conditions, but they belong to different drug classes and have different uses. Cariprazine is an atypical antipsychotic used for schizophrenia, bipolar I disorder, and as an add-on for major depressive disorder (MDD). Bupropion is an atypical antidepressant used for depression and seasonal affective disorder (SAD). Cariprazine is taken once daily as an oral capsule, while bupropion is available in various forms, including immediate-release, sustained-release, and extended-release tablets, with dosing frequency ranging from once to three times a day. Cariprazine is only available as a brand-name medication, whereas bupropion is available in generic form, making it more affordable. Common side effects of cariprazine include uncontrolled muscle movements and restlessness, while bupropion may cause dry mouth and trouble sleeping. Cariprazine can cause tardive dyskinesia, a serious movement disorder, while bupropion carries a risk of seizures, especially in those with a history of seizures or eating disorders.
